Mechanisms for histamine H1 receptor-mediated vasodilation in isolated canine lingual arteries.
Mechanisms for histamine H1 receptor-mediated vasodilation in isolated canine lingual arteries.
复制标题
离体犬舌动脉中组胺 H1 受体介导的血管舒张机制。
DOI：
10.1016/s0014-2999(97)10105-4
复制
发表时间：
1997
影响因子：
5
通讯作者：
M. Tsukada
中科院分区：
文献类型：
--
作者：
S. Chiba;M. Tsukada
采用插管法研究了组胺和选择性组胺受体亚型激动剂对离体和灌注犬舌动脉的影响。在用苯肾上腺素、组胺和选择性组胺h1受体激动剂预收缩的制剂中，2-吡啶乙胺以剂量相关的方式诱导双期血管反应，即血管收缩后血管扩张。选择性组胺h1受体拮抗剂苯海拉明可抑制组胺和2-吡啶乙胺的双相反应，而选择性组胺h2受体拮抗剂西咪替丁不影响双相反应。diapprit是一种选择性组胺h2受体激动剂，仅引起轻微的血管收缩，而西咪替丁不改变血管收缩。即使大剂量地马普利也不会引起血管舒张。组胺h3受体激动剂R-α-甲基组胺没有产生明显的血管反应。此外，组胺诱导的血管舒张部分被内皮细胞的去除所抑制，剩余的血管舒张被H1blockade所消除。因此，我们得出结论，犬舌动脉中存在丰富的组胺h1受体，可以介导血管收缩和血管舒张，组胺诱导的血管舒张部分是由于内皮依赖机制。
Histamine and selective histamine receptor subtype agonists' effects on isolated and perfused canine lingual arteries were investigated with the cannula insertion method. In preparations preconstricted with phenylephrine, histamine and a selective histamine H1receptor agonist, 2-pyridylethylamine induced a biphasic vascular response in a dose-related manner, i.e., vasoconstriction followed by vasodilatation. The biphasic responses to histamine and 2-pyridylethylamine were inhibited by diphenhydramine, a selective histamine H1receptor antagonist, but were not influenced by cimetidine, a selective histamine H2receptor antagonist. Dimaprit, a selective histamine H2receptor agonist, induced only a slight vasoconstriction which was not modified by cimetidine. Dimaprit never induced vasodilation even at a large dose. A histamine H3receptor agonist, R-α-methylhistamine, did not produce any significant vascular responses. Moreover, histamine-induced vasodilation was in part inhibited by removal of the endothelium, and the vasodilation remaining was abolished by H1blockade. Thus, it is concluded that in canine lingual arteries there are abundant histamine H1receptors which mediate both vasoconstriction and vasodilation, and that the histamine-induced vasodilation is in part due to endothelium-dependent mechanisms.