A study of betel quid carcinogenesis. 3. 3-(Methylnitrosamino)-propionitrile, a powerful carcinogen in F344 rats.
A study of betel quid carcinogenesis. 3. 3-(Methylnitrosamino)-propionitrile, a powerful carcinogen in F344 rats.
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槟榔致癌的研究。
DOI：
10.1093/carcin/5.9.1137
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发表时间：
1984
期刊：
影响因子：
4.7
通讯作者：
Hoffmann,D
中科院分区：
文献类型：
--
作者：
Wenke,G;Rivenson,A;Hoffmann,D
3-（甲基亚硝胺基）丙腈（MNPN）是由槟榔生物碱槟榔碱在温和的亚硝化条件下在体外合成的。看来MNPN很可能是在咀嚼槟榔时产生的，特别是当烟草被添加到槟榔中时。在皮下注射1.1 mmol MNPN 60个亚剂量后，所有15只雄性和15只雌性F344大鼠在24周内均发生肿瘤。其中26只老鼠至少在两个不同的器官中有肿瘤。27只大鼠患有食管肿瘤，21只鼻肿瘤，11只舌肿瘤，2只动物患有咽癌或前胃乳头状瘤。在溶剂对照组中未观察到肿瘤。这些数据表明，MNPN是一种强致癌物。
3-(Methylnitrosamino)propionitrile (MNPN) is formedin vitrounder mild nitrosation conditions from the major areca alkaloid arecoline. It appears likely that MNPN is generated during betel quid chewing especially when tobacco is added to the quid. Upon subcutaneous injection of 1.1 mmol of MNPN in 60 subdoses, all of the 15 male and of the 15 female F344 rats developed tumors within 24 weeks. Twenty-six of the rats had tumors in two different organs at least. Twenty-seven rats had esophageal tumors, 21 nasal tumors, 11 had tongue tumors and two animals had either pharyngeal carcinomas or papillomas of the forestomach. No tumors were observed in the solvent control group. These data indicate that MNPN is a potent carcinogen.