Astrocytes and Microglia and Their Potential Link with Autism Spectrum Disorders.
Astrocytes and Microglia and Their Potential Link with Autism Spectrum Disorders.
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DOI：
10.3389/fncel.2016.00021
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发表时间：
2016
影响因子：
5.3
通讯作者：
Bezzi P
中科院分区：
文献类型：
--
作者：
Petrelli F;Pucci L;Bezzi P
自闭症谱系障碍(ASD)的细胞机制(S)尚未完全了解，尽管已表明各种遗传和环境因素在其病因中起作用。随着越来越多的证据表明星形胶质细胞和小胶质细胞在突触成熟和功能中起主要作用，以及有证据表明ASD的胶质细胞功能缺陷，目前的一个假说是胶质细胞功能障碍直接导致了ASD的病理生理。本文就小胶质细胞和星形胶质细胞在突触发育中的作用及其在自闭症中的作用作一综述。
The cellular mechanism(s) underlying autism spectrum disorders (ASDs) are not fully understood although it has been shown that various genetic and environmental factors contribute to their etiology. As increasing evidence indicates that astrocytes and microglial cells play a major role in synapse maturation and function, and there is evidence of deficits in glial cell functions in ASDs, one current hypothesis is that glial dysfunctions directly contribute to their pathophysiology. The aim of this review is to summarize microglia and astrocyte functions in synapse development and their contributions to ASDs.