Early Visual Cortex Stimulation Modifies Well-Consolidated Perceptual Gains.
Early Visual Cortex Stimulation Modifies Well-Consolidated Perceptual Gains.
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早期视觉皮层刺激会改变巩固良好的感知增益。
DOI：
10.1093/cercor/bhaa215
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Censor,Nitzan
中科院分区：
文献类型：
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作者：
Shmuel,Dean;Frank,SebastianM;Sharon,Haggai;Sasaki,Yuka;Watanabe,Takeo;Censor,Nitzan
感知阈值可以通过视觉任务的重复练习来提高。一种已经获得并得到很好巩固的知觉技能是否可以被非侵入性地神经调节，从而揭示所涉及的神经机制？在这里，利用从突触到跨学习和记忆领域和动物模型的系统水平的重新激活的记忆的易感性，我们使用非侵入性脑刺激来神经调节良好巩固的重新激活的视觉感知学习，并揭示潜在的神经机制。受试者首先编码和巩固的视觉技能的记忆进行日常实践会议的任务。在另一天，巩固的视觉记忆被短暂地重新激活，然后在早期视觉皮层上进行低频，抑制性1 Hz重复经颅磁刺激，使用功能性磁共振成像单独定位。在最后一次会议上测量刺激后感知阈值。结果表明，调制感知阈值后，早期视觉皮层刺激，相对于控制刺激。一致的是，训练前的早期视觉皮层的训练和未训练的部分之间的静息状态功能连接预测感知阈值调制的大小。总之，这些结果表明，即使是以前巩固的人类知觉记忆也容易受到神经调节的影响，包括早期的视觉皮层处理。此外，非侵入性神经调节重新激活的感知学习的机会可能具有重要的临床意义。
Perception thresholds can improve through repeated practice with visual tasks. Can an already acquired and well-consolidated perceptual skill be noninvasively neuromodulated, unfolding the neural mechanisms involved? Here, leveraging the susceptibility of reactivated memories ranging from synaptic to systems levels across learning and memory domains and animal models, we used noninvasive brain stimulation to neuromodulate well-consolidated reactivated visual perceptual learning and reveal the underlying neural mechanisms. Subjects first encoded and consolidated the visual skill memory by performing daily practice sessions with the task. On a separate day, the consolidated visual memory was briefly reactivated, followed by low-frequency, inhibitory 1 Hz repetitive transcranial magnetic stimulation over early visual cortex, which was individually localized using functional magnetic resonance imaging. Poststimulation perceptual thresholds were measured on the final session. The results show modulation of perceptual thresholds following early visual cortex stimulation, relative to control stimulation. Consistently, resting state functional connectivity between trained and untrained parts of early visual cortex prior to training predicted the magnitude of perceptual threshold modulation. Together, these results indicate that even previously consolidated human perceptual memories are susceptible to neuromodulation, involving early visual cortical processing. Moreover, the opportunity to noninvasively neuromodulate reactivated perceptual learning may have important clinical implications.