The role of interleukin-1 in the pathogenesis of Lyme disease.
The role of interleukin-1 in the pathogenesis of Lyme disease.
复制标题
IL-1 在莱姆病发病机制中的作用。
DOI：
10.1111/j.1749-6632.1988.tb31840.x
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发表时间：
1988
影响因子：
5.2
通讯作者：
Benach,JL
中科院分区：
文献类型：
--
作者：
Habicht,GS;Beck,G;Benach,JL
白细胞介素-1（IL-1）是由单核细胞、巨噬细胞以及多种相关和非相关细胞产生的细胞因子家族。它是一种主要的免疫调节蛋白，也是针对感染、炎症和免疫损伤的非特异性宿主防御机制的分子协调者。当宿主面临内源性或外源性挑战时，会发生一系列戏剧性的变化，其中大部分是针对消除刺激。这些变化是急性期反应的一部分，发生在几个小时的挑战。其他的可能会在较长的时间内演变，并建议持续性疾病或慢性感染。急性期反应是全身性的，包括发热、肝急性期蛋白合成增加、血浆铁和锌降低、白细胞增多、疲劳和食欲下降。急性期反应由IL-1介导。莱姆病，首先被认为是在老莱姆病，CT关节炎的焦点爆发，是由感染螺旋体伯氏疏螺旋体的Zxodes蜱叮咬引起的。原发性莱姆病包括皮肤损害，慢性游走性红斑（ECM），随后可能出现涉及心血管和中枢及外周神经系统的继发性表现。第三期莱姆病的特征是复发性疼痛和大关节肿胀。60%的莱姆病患者在蜱叮咬后数月至数年内出现关节症状。4在许多情况下，关节炎是疾病的唯一临床表现。关节炎累及大关节，组织学上与类风湿性关节炎相似。“虽然莱姆病的表现很普遍，可能很严重，但要证明受影响组织中存在螺旋体相对困难。银染偶尔在皮肤病变中显示螺旋体，6特别是莱姆病患者的慢性游走性红斑、心肌和滑膜的前缘。从血液中培养出螺旋体的情况很少3。6和滑液。莱姆病患者中很少发现伯氏疏螺旋体，这使我们寻找具有放大生物体致病性能力的螺旋体和宿主衍生因子。我们以前已经表明，莱姆病螺旋体是一个有效的诱导剂IL-1的生产培养的人类和小鼠单核吞噬细胞。“此外，我们还报告说，B。本工作得到了美国国立卫生研究院批准号AR 36028的支持。
Interleukin-1 (IL-1) is a family of cytokines produced by monocytes, macrophages, and a variety of related and nonrelated cells. It is a major immunoregulatory protein and is also the molecular orchestrator of nonspecific host defense mechanisms against infectious, inflammatory, and immunologic insults. When a host is faced with an endogenous or exogenous challenge a dramatic series of changes occurs, most of which are directed at eliminating the stimulus. These changes are part of the acute phase response that takes place within a few hours of challenge. Others may evolve over longer periods and suggest persistent disease or chronic infection. The acute phase response is systemic and includes fever, increased synthesis of hepatic acute phase proteins, decreased plasma iron and zinc, leukocytosis, fatigue, and decreased appetite. The acute phase response is mediated by IL-1. I Lyme disease, first recognized as a focal outbreak of arthritis in Old Lyme, CT,'is caused by the bite of an Zxodes tick infected with the spirochete Borrelia burgdorferi. Primary Lyme disease consists of a skin lesion, erythema chronicum migrans (ECM), which may be followed by secondary manifestations involving the cardiovascular and the central and peripheral nervous sy~ terns.~ Tertiary Lyme disease is characterized by recurrent pain and swelling of the large joints. Sixty percent of Lyme disease patients experience joint symptoms that develop months to years following the tick bite. 4 In many cases, arthritis is the only clinical manifestation of the disease.'Arthritis involves the large joints and is histologically similar to rheumatoid arthritis.'Although the manifestations of Lyme disease are widespread and may be severe, it has been relatively difficult to demonstrate the presence of the spirochete in affected tissues. Silver staining has occasionally shown spirochetes in skin lesions, 6 especially the leading edge of erythema chronicum migrans, the myocardium'and synoviae'from Lyme disease patients. Spirochetes have been cultured only infrequently from blood3. 6 and synovial fluid^.^ That Borrelia burgdorferi are rarely identified in Lyme disease patients has led us to search for both spirochete and host-derived factors with the capacity to amplify the pathogenicity of the organism. We have previously shown the Lyme disease spirochete to be a potent inducer of IL-I production by cultured human and murine mononuclear phagocytes." In addition, we have reported that B. burgdorferi possess a lipopolysaccharide (LPS) that aThis work was supported by grant no. AR36028 from the National Institutes of Health.