BOTH EPSTEIN-BARR-VIRUS (EBV)-ENCODED TRANS-ACTING FACTORS, EB1 AND EB2, ARE REQUIRED TO ACTIVATE TRANSCRIPTION FROM AN EBV EARLY PROMOTER
BOTH EPSTEIN-BARR-VIRUS (EBV)-ENCODED TRANS-ACTING FACTORS, EB1 AND EB2, ARE REQUIRED TO ACTIVATE TRANSCRIPTION FROM AN EBV EARLY PROMOTER
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DOI：
10.1002/j.1460-2075.1986.tb04635.x
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发表时间：
1986-12-01
期刊：
影响因子：
11.4
通讯作者：
SERGEANT, A
中科院分区：
文献类型：
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作者：
CHEVALLIERGRECO, A;MANET, E;SERGEANT, A
我们已经确定了两个eb病毒（EBV）反式作用因子，它们参与了潜伏感染的Raji细胞中EBV早期启动子的转录激活。在Raji细胞中，由开放阅读框（ORF） BZIFl编码的因子EBl的表达是必要的，足以破坏潜伏期。然而，由ORF BMLF1-BSLF2编码的因子EB2在Raji细胞中单独表达时不会破坏潜伏期。EBV可激活的早期启动子的表达取决于EB1和EB2的存在。
We have identified two Epstein-Barr virus (EBV) trans-acting factors which are involved in the transcriptional activation of EBV early promoters in latently infected Raji cells. In Raji cells, expression of the factor EBl encoded by the open reading frame (ORF) BZIFl is necessary and sufficient to disrupt latency. However, factor EB2 encoded by the ORF BMLF1-BSLF2 does not distrupt latency when expressed alone in Raji cells. Expression of an EBV activatable early promoter depends on the presence of both EB1 and EB2.