Gender-specific modulation of short-term neuroplasticity in the visual cortex induced by transcranial direct current stimulation
Gender-specific modulation of short-term neuroplasticity in the visual cortex induced by transcranial direct current stimulation
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DOI：
10.1017/s0952523808080097
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发表时间：
2008-01-01
影响因子：
1.9
通讯作者：
Paulus, Walter
中科院分区：
文献类型：
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作者：
Chaieb, Leila;Antal, Andrea;Paulus, Walter
经颅直流电刺激（tDCS）是一种调节皮质兴奋性水平的非侵入性方法。在这项研究中，重新分析了之前在tDCS之前和之后进行的多项实验中收集的数据，以研究性别差异与神经可塑性效应之间的相关性。视觉诱发电位（VEP）、光幻视阈值（PT）和对比敏感度测量（CS）被用作初级视皮层兴奋性的指标。数据显示，tDCS刺激后10 min的阴极诱导兴奋性效应在性别间无显著差异。然而，在阳极方向的刺激揭示了性别特异性的影响：在女性中，阳极刺激提高皮质兴奋性显着相比，年龄匹配的男性受试者组。刺激后即刻，男性和女性受试者之间无显著差异。这些结果表明，性别差异存在于人类的视觉皮层，并可能受到调节性神经递质或性腺激素的影响，反映短期的神经可塑性效应。
Transcranial direct current stimulation (tDCS) is a non-invasive method of modulating levels of cortical excitability. In this study, data gathered over a number of previously conducted experiments before and after tDCS, has been re-analyzed to investigate correlations between sex differences with respect to neuroplastic effects. Visual evoked potentials (VEPs), phosphene thresholds (PTs), and contrast sensitivity measurements (CSs) are used as indicators of the excitability of the primary visual cortex. The data revealed that cathodally induced excitability effects 10 min post stimulation with tDCS, showed no significant difference between genders. However, stimulation in the anodal direction revealed sex-specific effects: in women, anodal stimulation heightened cortical excitability significantly when compared to the age-matched male subject group. There was no significant difference between male and female subjects immediately after stimulation. These results indicate that sex differences exist within the visual cortex of humans, and may be subject to the influences of modulatory neurotransmitters or gonadal hormones which mirror short-term neuroplastic effects.