Do CRISPR Germline Ethics Statements Cut It?
Do CRISPR Germline Ethics Statements Cut It?
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DOI：
10.1089/crispr.2017.0024
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发表时间：
2018-04-01
期刊：
影响因子：
3.7
通讯作者：
Brokowski, Carolyn
中科院分区：
文献类型：
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作者：
Brokowski, Carolyn
在CRISPR-Cas9的推动下，基因组工程创新的非凡浪潮引发了世界范围内的科学和伦理不确定性。关于人类是否应该允许可遗传的基因组编辑，也就是说，修改基因组材料使其可以传递给后代，在道德上是否可以接受，这在全球范围内引起了极大的关注。在这里，我审查了国际社会在过去3年内就这一有争议的问题发表的61项道德声明，并考虑了这些声明的总体立场和局限性。尽管许多声明不能充分处理所有重要的考虑因素，但它们可能会推动辩论以及国家和国际法以及公共政策。
The extraordinary wave of genomic-engineering innovation, driven by CRISPR-Cas9, has sparked worldwide scientific and ethical uncertainty. Great concern has arisen across the globe about whether heritable genome editing should be permissible in humansthat is, whether it is morally acceptable to modify genomic material such that the "edit" is transferable to future generations. Here I examine 61 ethics statements released by the international community within the past 3 years about this controversial issue and consider the statements' overarching positions and limitations. Despite their inability to fully address all important considerations, many of the statements may advance debate and national and international law and public policy.