The regulation of abscission by multi-protein complexes
The regulation of abscission by multi-protein complexes
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DOI：
10.1242/jcs.083949
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发表时间：
2011-10-01
影响因子：
4
通讯作者：
Gould, Gwyn W.
中科院分区：
文献类型：
--
作者：
Neto, Helia;Gould, Gwyn W.
胞质分裂的终末阶段--称为脱落的过程--是连接两个子细胞的细小的细胞间桥梁的切断。最近的工作为解决这种微管-致密膜桥的机制提供了新的见解，并强调了多蛋白组装在脱落的不同方面的重要作用。它们包括运输所需的内体分选复合体(ESCRT)，它似乎在最终的分裂事件中起决定性作用，以及囊泡系留复合体，它可能在较早阶段发挥作用，并可能用于准备脱落部位。在这里，我们综述了最近关于这些复合体的结构、功能和调节与脱落相关的研究。我们主要专注于哺乳动物细胞胞质分裂的研究。然而，其他系统中的细胞分裂，如植物和古细菌，也被考虑在内，反映了细胞分裂过程中膜断裂过程的机械性保守。
The terminal stage of cytokinesis - a process termed abscission - is the severing of the thin intercellular bridge that connects the two daughter cells. Recent work provides new insight into the mechanism by which this microtubule-dense membrane bridge is resolved, and highlights important roles for multi-protein assemblies in different facets of abscission. These include the endosomal sorting complex required for transport (ESCRT), which appears to have a decisive role in the final scission event, and vesicle tethering complexes, which potentially act at an earlier stage, and might serve to prepare the abscission site. Here, we review recent studies of the structure, function and regulation of these complexes as related to abscission. We focus largely on studies of cytokinesis in mammalian cells. However, cell division in other systems, such as plants and Archae, is also considered, reflecting the mechanistic conservation of membrane-scission processes during cell division.