Feline Insular Amyloid: Association with Diabetes Mellitus
Feline Insular Amyloid: Association with Diabetes Mellitus
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猫岛淀粉样蛋白：与糖尿病的关联
DOI：
10.1177/030098588101800507
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发表时间：
1981
影响因子：
2.4
通讯作者：
K. Johnson
中科院分区：
文献类型：
--
作者：
B. Yano;D. W. Hayden;K. Johnson
在31只患有糖尿病的家猫中，20只（65%）的胰岛有淀粉样蛋白沉积（即岛状淀粉样蛋白）。在我们之前的研究中，糖尿病猫和年龄匹配的非糖尿病猫的岛状淀粉样变性发病率（p = 0.34）没有显著差异。然而，与非糖尿病猫相比，糖尿病猫的胰岛淀粉样蛋白平均百分比（p = < 0.005）和丰富淀粉样蛋白沉积的胰岛平均百分比（p = <005）显著更高。这些结果表明，胰岛淀粉样变性和糖尿病是有因果关系的，而不是简单的与衰老相关的并发疾病。虽然胰岛淀粉样变性与糖尿病发病的具体关系尚未确定，但胰岛细胞功能异常可能先于糖尿病状态和胰岛淀粉样蛋白沉积。
Of 31 domestic cats with diabetes mellitus, 20 (65%) had amyloid deposits in their pancreatic islets (i.e., insular amyloid). The incidence of insular amyloidosis (p = 0.34) was not significantly different between diabetic and age-matched, non-diabetic cats from our previous study. Diabetic cats, however, had a significantly higher mean percentage of islets with amyloid (p = <.005) and a significantly higher mean percentage of islets with abundant amyloid deposits (p = <005) than did non-diabetic cats. These results suggest that insular amyloidosis and diabetes are causally related and are not simply concurrent diseases associated with aging. Although the specific relationship of insular amyloidosis to the pathogenesis of diabetes mellitus was not determined, a functional islet cell abnormality probably precedes the diabetic state and the deposition of insular amyloid.