Microfluidic Wheatstone bridge for rapid sample analysis
Microfluidic Wheatstone bridge for rapid sample analysis
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DOI：
10.1039/c1lc20604d
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发表时间：
2011-01-01
期刊：
影响因子：
6.1
通讯作者：
Schroeder, Charles M.
中科院分区：
文献类型：
--
作者：
Tanyeri, Melikhan;Ranka, Mikhil;Schroeder, Charles M.
我们开发了经典惠斯通电桥电路的微流体模拟，用于以流通设备格式对解决方案进行自动实时采样。我们展示了使用片上薄膜阀对“桥”微通道中的流速和流向进行精确控制，该薄膜阀充当集成的“可变电阻器”。我们采用自动反馈控制机制来动态调节阀门开度，从而控制桥上的压降并精确控制桥通道中的流体流量。在关键阀门开度时，可以通过平衡惠斯通电桥装置中的流阻来完全停止桥通道中的流动，这有利于桥通道中快速、按需的流体采样。在本文中，我们介绍了设备操作的底层机制，并报告了决定设备性能的关键设计参数。总体而言，微流控惠斯通电桥代表了一种用于片上流量控制和样品操作的新型多功能方法。
We developed a microfluidic analogue of the classic Wheatstone bridge circuit for automated, real-time sampling of solutions in a flow-through device format. We demonstrate precise control of flow rate and flow direction in the "bridge'' microchannel using an on-chip membrane valve, which functions as an integrated "variable resistor''. We implement an automated feedback control mechanism in order to dynamically adjust valve opening, thereby manipulating the pressure drop across the bridge and precisely controlling fluid flow in the bridge channel. At a critical valve opening, the flow in the bridge channel can be completely stopped by balancing the flow resistances in the Wheatstone bridge device, which facilitates rapid, on-demand fluid sampling in the bridge channel. In this article, we present the underlying mechanism for device operation and report key design parameters that determine device performance. Overall, the microfluidic Wheatstone bridge represents a new and versatile method for on-chip flow control and sample manipulation.