Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles.
Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles.
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DOI：
10.1021/acs.orglett.5b03708
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发表时间：
2016-02-19
期刊：
影响因子：
5.2
通讯作者：
Rawal VH
中科院分区：
文献类型：
--
作者：
Montgomery TD;Rawal VH
本文报道了一种通过钯催化环化反应模块化合成高取代哌嗪及其相关双氮杂环化合物的新方法。该方法将炔丙基单元的两个碳与各种二胺组分偶联，以通常良好至优异的产率和高区域和立体化学控制提供氮杂环。
We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control.