Role of 3-aminopropyltriethoxysilane in the preparation of mesoporous silica nanoparticles for ibuprofen delivery: Effect on physicochemical properties
Role of 3-aminopropyltriethoxysilane in the preparation of mesoporous silica nanoparticles for ibuprofen delivery: Effect on physicochemical properties
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DOI：
10.1016/j.micromeso.2013.06.041
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发表时间：
2013-11-01
影响因子：
5.2
通讯作者：
Ahmad, A.
中科院分区：
文献类型：
--
作者：
Kamarudin, N. H. N.;Jalil, A. A.;Ahmad, A.
研究了基于介孔二氧化硅纳米颗粒的药物控制释放平台的开发。合成了介孔二氧化硅纳米粒子（MSN），并采用共缩合法（MSNco）和后接枝法（MSNepost）对MSN进行了氨丙基三乙氧基硅烷（APTES）改性。X射线衍射（XRD）和透射电子显微镜（TEM）的数据证实了有序的介观结构的二氧化硅纳米粒子的形成。然后在布洛芬固定和释放上测试MSN的性能。结果表明，未改性的MSN对布洛芬的固定化率和吸附量最高（98%），MSNpost对布洛芬的吸附量最高（78%）。(71%），表明改性方法不是所研究吸附的主导因素。实际上，根据FT-IR结果，发现硅醇基团密度是影响吸附的贡献因素。还采用模拟生物流体考察了药物的体外释放。在20 h内，MSNco显示布洛芬的释放最快（100%），其次是MSN（50%）和MSNpost（38%）。孔径和胺基都影响释放过程的速率。从结果来看，MSN和MSNpost具有适合药物缓慢释放的特征，其在限定的时间内提供恒定的释放，以避免重复给药。而MSN可以最好地用作快速释放系统，其提供药物释放的初始爆发以实现快速和最大的缓解。(C)2013 Elsevier Inc. All rights reserved.
The development of mesoporous silica nanoparticle-based platforms for a controlled drug delivery was studied. Mesoporous silica nanoparticles (MSN) was synthesized and modified with 3-aminopropyltriethoxysilane (APTES) using co-condensation (MSNco) and post-grafting (MSNEpost) methods. X-ray diffraction (XRD) and transmission electron microscopy (TEM) data confirmed the formation of ordered mesostructured silica nanoparticles. The performance of MSNs was then tested on an ibuprofen immobilization and release. The results revealed that unmodified MSN demonstrated the best immobilization rate and capacity of ibuprofen (98%), MSNpost exhibited higher ibuprofen adsorption (78%) as compared to MSNco. (71%), suggesting the modification method is not the dominant factor for the adsorption studied. In fact, according to the FT-IR results, the silanol groups density was found to be the contributing factor that affected the adsorption. The in vitro drug release was also investigated with simulated biological fluids. In 20 h, MSNco showed the fastest release of ibuprofen (100%), followed by MSN (50%) and MSNpost (38%). Both pore size and amine groups influenced the rate of the release process. From the results, MSN and MSNpost is suggested to have suitable features for slow drug release which provides constant release over a defined period to avoid repeated administration. While MSN, could be best employed as a fast release system that provides initial burst of drug release to achieve rapid and maximum relief. (C) 2013 Elsevier Inc. All rights reserved.