Effect of aging on foveolar choroidal circulation.
Effect of aging on foveolar choroidal circulation.
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DOI：
10.1001/archopht.116.2.150
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发表时间：
1998-02
影响因子：
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通讯作者：
J. Grunwald;S. Hariprasad;J. Dupont
中科院分区：
文献类型：
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作者：
J. Grunwald;S. Hariprasad;J. Dupont
目的探讨增龄对正常眼底黄斑区脉络膜血流量(ChBflow)的影响。方法用激光多普勒血流仪测定脉络膜血流量。29例(29眼)正常人，年龄15~76岁(平均+/-SD，42+/-18岁)。通过要求受试者注视探测的激光光束，测量黄斑中心凹区域的相对脉络膜血流速度(ChBVel)、脉络膜血容量(ChBVol)和脉络膜血流量。结果CHBVol与年龄呈显著负相关(R=-0.52，P=0.004)，ChBFlow与年龄呈显著负相关(R=-0.54，P=0.003)。CHBVel与受试者年龄无显著相关性(R=0.07，P=0.70)。CHBVol和ChBFlow在15~45岁年龄组(均值+/-SD，0.48+/-0.20和18.9+/-5.8AU)与46~76岁年龄组(均值+/-SD，0.34+/-0.11AU和13.3+/-3.3AU；非配对t检验，P=0.04和P=0.007)之间有显著差异。结论在研究对象中，黄斑中心凹血流量随年龄增长而减少。这种改变可能与脉络膜毛细血管的密度和直径随年龄增长而减少有关。
OBJECTIVE To determine the effect of aging on choroidal blood flow (ChBFlow) in the foveolar region of the normal ocular fundus. METHOD Choroidal blood flow was determined using laser Doppler flowmetry. Twenty-nine eyes of 29 normal subjects whose ages ranged from 15 to 76 years (mean+/-SD, 42+/-18 years) were included in this study. Relative choroidal blood velocity (ChBVel), choroidal blood volume (ChBVol), and ChBFlow were determined in the foveolar region by asking the subjects to fixate on the probing laser beam. RESULTS Significant negative correlations were observed between ChBVol and the subject's age (R=-0.52, P=.004) and between ChBFlow and the subject's age (R=-0.54, P=.003). No significant correlation was detected between ChBVel and the subject's age (R=0.07, P=.70). Significant differences were observed in ChBVol and ChBFlow between the younger subjects aged 15 to 45 years (mean+/-SD, 0.48+/-0.20 arbitrary units [AU] and 18.9+/-5.8 AU, respectively) and the older ones aged 46 to 76 years (mean+/-SD, 0.34+/-0.11 AU and 13.3+/-3.3 AU, respectively; unpaired Student t test, P=.04 and P=.007, respectively). CONCLUSION In the subjects studied, foveolar ChBFlow decreases with age. This change is probably related to the decrease in density and diameter of the choriocapillaries that occurs with increasing age.