Comparison between dodecanedioic acid and long-chain triglycerides as all energy source in liquid formula diets
Comparison between dodecanedioic acid and long-chain triglycerides as all energy source in liquid formula diets
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DOI：
10.1177/014860719902300280
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发表时间：
1999-03-01
影响因子：
3.4
通讯作者：
Gasbarrini, G
中科院分区：
文献类型：
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作者：
Mingrone, G;De Gaetano, A;Gasbarrini, G
背景：二羧酸（DA）是一种具有高能量密度的水溶性物质，被建议作为一种营养用途的脂质底物。本研究的目的是研究口服给药后葡萄糖与DA或长链甘油三酯（LCT）代谢之间的相互作用。方法：五名健康志愿者分别服用含有十二烯二酸（C12, 12原子DA）或LCT以及葡萄糖和氨基酸的两种试验餐。在C12粉中加入一定量的c -14-十二烷二酸来回收过期的痕量CO，并估算出C12的最小氧化速率。葡萄糖、胰岛素和C12血浆水平在测试餐后360分钟测量。在研究期间采用间接量热法。结果：口服LCTs对自身氧化无促进作用。相反，C12被迅速氧化，至少21.9% +/- 8.3%的给药量产生回收的过期CO。这种代谢命运的差异反映在对葡萄糖的节约作用上：C12组的呼吸商和碳水化合物氧化显著低于LCT组（p < 0.05），呼吸商（RQ）差异为0.024 +/- 0.015，碳水化合物氧化差异为0.791 +/- 0.197 kJ/min。特别是，与基础相比，LCT组碳水化合物氧化增加了54%，而C12组仅增加了28%。LCT组RQ较基础组增加5.8%，而C12组仅增加3.0%。结论：这些结果显示了常规脂类和DAs之间的基本代谢差异，这是DAs在临床营养中可能发挥作用的基础。当十二烷二酸作为能量来源可用时，剩余葡萄糖的命运很可能以糖原形式储存。
Background: Dicarboxylic acids (DA) are water-soluble substances with high-energy density proposed as an alternative Lipid substrate-for nutrition purposes. The aim of the present-study was to investigate the interaction between glucose and DA or long-chain triglyceride (LCT) metabolism after oral administration. Methods: two test meals containing either dodecanedioic acid (C12, the 12-atom DA) or LCT, together with glucose and amino acids, were each administered to five healthy volunteers. Tracer amounts of C-14-dodecanedioic acid were added to the C12 meal to recover expired traced CO, and estimate the minimum rate of C12 oxidation. Glucose, insulin, and C12 plasma levels were measured for 360 minutes after the test meal. Indirect calorimetry was performed for the duration of the study. Results: LCTs proved ineffective in promoting their own oxidation after oral administration. On the contrary, C12 was promptly oxidized, a minimum of 21.9% +/- 8.3% of the administered amount giving rise to the recovered expired CO,. This difference in metabolic fate was reflected in a sparing effect on glucose: suprabasal respiratory quotient and suprabasal carbohydrate oxidation were significantly (p < .05) lower under C12 administration than under LCT administration, with a difference of 0.024 +/- 0.015 in respiratory quotient (RQ) and a difference of 0.791 +/- 0.197 kJ/min in carbohydrate oxidation. Ln particular, carbohydrate oxidation increased by 54% over basal with LCT but only by 28% with C12 administration. RQ increased over basal by 5.8% with LCT but only by 3.0% with C12 administration. Conclusions: These results show a fundamental metabolic difference between conventional Lipids and DAs, which is the basis for a possible role of DAs in clinical nutrition. The fate of spared glucose is likely to be storage in glycogen form when dodecanedioic acid is made available as an energy source.