Effect of neonatal handling and paternal care on offspring cognitive development in the monogamous California mouse (Peromyscus californicus)
Effect of neonatal handling and paternal care on offspring cognitive development in the monogamous California mouse (Peromyscus californicus)
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DOI：
10.1016/j.yhbeh.2003.09.017
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发表时间：
2004-06-01
影响因子：
3.5
通讯作者：
Brown, RE
中科院分区：
文献类型：
--
作者：
Bredy, TW;Lee, AW;Brown, RE
在实验室的大鼠和小鼠中，新生儿的处理增强了成年后对海马体的依赖学习，这一影响是由母亲对被处理的幼鼠行为的改变所介导的。在这项研究中，我们研究了出生后早期新生儿处理和双亲照料之间的相互作用及其对成年加州小鼠(Permyscus CalforNicus)认知功能的影响。我们描述了有父亲陪伴和无父亲陪伴的家庭在出生前15天的父母行为。然后，我们评估了60天后交配和雌性后代在巴恩斯迷宫和物体识别测试中的认知表现。我们发现，在没有父亲的家庭中，幼崽接受的舔和梳理的数量减少了。到出生后12-15天，在有父亲陪伴的无人照看的家庭中，没有父亲的家庭的舔舔和梳理相当于没有父亲的家庭。在父亲在场的雄性小鼠中处理增强的新对象识别，而在雌性小鼠中没有影响。在非处理组中，父亲的存在对雄性或雌性小鼠的物体识别学习没有影响。操作还增强了巴恩斯迷宫中的空间学习。在无人照看的家庭中，父亲的存在似乎对男性后代的空间学习没有影响。有趣的是，没有处理的、没有父亲的雌性后代的空间学习与处理过的动物相似。幼崽接受的舔和梳理的平均数量是。与Barnes迷宫反转训练第一天的平均错误数呈负相关。这些数据支持了之前的研究结果，即新生儿的处理有助于成年后的学习和记忆，表明在特定的环境条件下，幼崽对父亲照顾的反应存在性别差异，并进一步证明了积极的父母投资对后代认知发展的重要性。(C)2004 Elsevier Inc.保留所有权利。
In the laboratory rat and mouse, neonatal handling enhances hippocampal-dependent learning in adulthood, an effect mediated by changes in maternal behavior toward the handled young. In the present study, we examined the interaction between neonatal handling and biparental care during the early postnatal period and its effect on cognitive function in adult California mice (Peromyscus californicus). We characterized the parental behavior of handled and nonhandled father-present and father-absent families over the first 15 days of life. We then assessed cognitive performance of mate and female offspring in the Barnes maze and object recognition test after they were 60 days of age. We found that the amount of licking and grooming received by pups was decreased in father-absent families. By postnatal days 12-15, licking and grooming in handled, father-absent families were equivalent to that of nonhandled, father-present families. Handling enhanced novel object recognition in father-present male mice with no effect in females. In the nonhandled group, the presence of the father had no effect on object recognition learning in male or female mice. Handling also enhanced spatial learning in the Barnes maze. In nonhandled families, the presence of the father appeared to have no effect on spatial learning in the male offspring. Interestingly, spatial learning in nonhandled, father-absent, female offspring was similar to that of handled animals. The average amount of licking and grooming received by pups was. negatively correlated with the average number of errors made on the first day of reversal training in the Barnes maze. These data support previous findings that neonatal handling facilitates learning and memory in adulthood, suggest that under certain environmental conditions, there is a sex difference in the response of pups to paternal care, and further demonstrate the importance of active parental investment for offspring cognitive development. (C) 2004 Elsevier Inc. All rights reserved.