Evidence for the existence of major depression with and without anxiety features.
Evidence for the existence of major depression with and without anxiety features.
复制标题
有或没有焦虑特征的重度抑郁症存在的证据。
DOI：
10.1159/000284842
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发表时间：
1994
期刊：
影响因子：
3.6
通讯作者：
Schotte,C
中科院分区：
文献类型：
--
作者：
Maes,M;Meltzer,HY;Cosyns,P;Schotte,C
一些研究报道了抑郁症和焦虑症之间的共病。本研究调查了单相抑郁症发作期间焦虑症状的发生。采用汉密尔顿焦虑状态评定量表（HAM-A）对73例住院抑郁症患者进行评定，根据DSM-III标准分为轻度（300.40、309.00）、重度抑郁症无（296.X2）和伴有（296.X3）抑郁症。主成分（PC）分析发现三个可解释的PC：躯体焦虑，抑郁焦虑重叠，焦虑情绪行为因素。与轻度抑郁症相比，重度抑郁症患者的总HAM-A评分、上述三项PC评分和所有HAM-A项目评分（除一般躯体肌肉和泌尿生殖系统症状外）均显著较高。聚类分析产生了两个稳定的，定性不同的集群：即一个有严重的焦虑和一个没有或最小的焦虑;六个最具鉴别力的症状是：紧张，行为在采访（一般或生理），呼吸，泌尿生殖系统和自主神经症状。高达95.4%的患者被分配到严重的焦虑集群是严重的抑郁症。结果表明，重性抑郁症可以分为两个性质不同的类，即重性抑郁症与不焦虑特征。
Several studies have reported on comorbidity between depression and anxiety. The present study investigates the occurrence of anxiety symptoms during an episode of unipolar depression. The authors administered the 15-item Rating Scale for Anxiety States of Hamilton (HAM-A) to 73 depressed inpatients categorized according to DSM-III criteria into minor (300.40,309.00), major depression without (296.X2) and with (296.X3) melancholia. Principal-component (PC) anylsis revealed three inter-pretable PCs: a somatic anxiety, a depression-anxiety overlap, and an anxious mood-behavior factor. Subjects with major depression showed significantly higher ratings on total HAM-A score, the three above PCs, and on all HAM-A items (except general somatic muscular and genitourinary symptoms) than subjects with minor depression. A cluster analysis generated two stable, qualitatively distinct clusters: i.e. one with severe anxiety and one with no or minimal anxiety; the six most discriminating symptoms were: tension, behavior at interview (general or physiological), respiratory, genitourinary and autonomic symptoms. Up to 95.4% of patients allocated to the severe anxiety cluster were major depressives. The results suggest that major depression may be divided into two qualitatively distinct classes, i.e. major depression with and without anxiety features.