Overall and cause-specific mortality in Korean patients with inflammatory bowel disease: A hospital-based cohort study
Overall and cause-specific mortality in Korean patients with inflammatory bowel disease: A hospital-based cohort study
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DOI：
10.1111/jgh.13596
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发表时间：
2017-04-01
影响因子：
4.1
通讯作者：
Yang, Suk-Kyun
中科院分区：
文献类型：
--
作者：
Lee, Ho-Su;Choe, Jaewon;Yang, Suk-Kyun
背景和目的：关于非白人人群炎症性肠病死亡率的数据有限。在此，我们评估了韩国炎症性肠病患者医院队列的总体死亡率和特定原因死亡率。方法：我们确定了 1977 年至 2013 年间诊断的 2414 名克罗恩病患者和 2798 名溃疡性结肠炎患者的死亡率。计算了几个人口统计学和表型亚组的标准化死亡率。结果：在平均 9 年随访期间，114 名患者死亡：35 名克罗恩病患者死亡79 名患有溃疡性结肠炎。克罗恩病的总体标准化死亡率为 1.40（95% 置信区间：0.97-1.94），溃疡性结肠炎的总体标准化死亡率为 0.73（0.58-0.91）。在克罗恩病中，女性、年龄 10 岁、诊断时患有回结肠疾病、肛周瘘、肠切除和曾经使用皮质类固醇与较高的死亡率相关。溃疡性结肠炎，男性，诊断时年龄 >= 30 岁，病程
Background and Aim: Limited data are available regarding mortality from inflammatory bowel disease in non-Caucasian populations. Herein, we evaluated overall and cause-specific mortality in a hospital-based cohort of Korean inflammatory bowel disease patients.Methods: We determined mortality in 2414 Crohn's disease patients and 2798 ulcerative colitis patients diagnosed between 1977 and 2013. Standardized mortality ratios were calculated in several demographic and phenotypic subgroups.Results: During the mean 9-year follow up, 114 patients died: 35 with Crohn's disease and 79 with ulcerative colitis. The overall standardized mortality ratios were 1.40 (95% confidence interval: 0.97-1.94) in Crohn's disease and 0.73 (0.58-0.91) in ulcerative colitis. In Crohn's disease, female sex, age 10years, ileocolonic disease at diagnosis, perianal fistula, intestinal resection, and ever-use of corticosteroids were associated with higher mortality. In ulcerative colitis, male sex, age >= 30years at diagnosis, disease duration