Examination of GABAergic and dopaminergic compounds in the acquisition of nicotine-conditioned hyperactivity in rats.
Examination of GABAergic and dopaminergic compounds in the acquisition of nicotine-conditioned hyperactivity in rats.
复制标题
检查 GABA 能和多巴胺能化合物在大鼠获得尼古丁条件性多动症中的作用。
DOI：
10.1159/000048682
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发表时间：
2002
影响因子：
3.2
通讯作者：
Bevins,RickA
中科院分区：
文献类型：
--
作者：
Palmatier,MatthewI;Bevins,RickA
在大鼠中，在不同的环境中反复与尼古丁（0.421 mg/kg碱，s.c.）在没有任何药物的情况下引起活动的增加。这种过度活跃表明环境和尼古丁之间存在巴甫洛夫条件关联。我们研究了多巴胺D1受体拮抗剂（SCH-23390）、D2/D3受体拮抗剂（依替氯必利）或GABA受体激动剂（巴氯芬）是否能预防尼古丁条件性多动症的发生。在盐水预处理的大鼠中，急性尼古丁抑制了条件反射阶段的活动（即环境-尼古丁配对）;慢性尼古丁刺激活动。SCH-23390（0.01 mg/kg，i. p.）预处理减弱尼古丁的激活作用而不影响对照。依替氯必利（0.03-0.07 mg/kg，i. p.）和巴氯芬（0.625和1.25mg/kg，i. p.）并不影响尼古丁诱导的活性在选择性的方式。无论预处理药物，大鼠获得的环境尼古丁协会在无药试验中的索引。SCH-23390不能阻断尼古丁条件性运动活动的获得是值得注意的，因为在过去的研究中，SCH-23390阻断了习得性关联的表达。
In rats, a distinct environment repeatedly paired with nicotine (0.421 mg/kg base, s.c.) comes to evoke an increase in activity in the absence of any drug. This hyperactivity indicates a Pavlovian-conditioned association between the environment and nicotine. We investigated whether a dopamine D1receptor antagonist (SCH-23390), a D2/D3antagonist (eticlopride) or a GABABagonist (baclofen) would prevent the acquisition of nicotine-conditioned hyperactivity. In saline-pretreated rats, acute nicotine suppressed activity during the conditioning phase (i.e. environment-nicotine pairings); chronic nicotine stimulated activity. Pretreatment with SCH-23390 (0.01 mg/kg, i.p.) attenuated the activating effects of nicotine without affecting controls. Eticlopride (0.03–0.07 mg/kg, i.p.) and baclofen (0.625 and 1.25 mg/kg, i.p.) did not affect nicotine-induced activity in a selective manner. Regardless of the pretreatment drug, rats acquired the environment-nicotine association as indexed in a drug-free test. The inability of SCH-23390 to block the acquisition of nicotine-conditioned locomotor activity is notable because in past research SCH-23390 blocked expression of the learned association.