Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer.
Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer.
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DOI：
10.1016/j.tips.2015.11.007
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发表时间：
2016-03
影响因子：
13.8
通讯作者：
Chhipa RR
中科院分区：
文献类型：
--
作者：
Dasgupta B;Chhipa RR
AMP激酶（AMPK）是一种进化上保守的酶，对各种生理和病理条件的适应性反应所必需的。AMPK执行许多细胞功能，其中一些经常被认为是相互矛盾的。虽然AMPK对胚胎生长和发育至关重要，但它对成体组织的全部影响在生物体在真实的世界中面临的压力情况下才能显示出来。关于其细胞功能，特别是在癌症中的功能的报道是有趣的，并且越来越多的AMPK激活剂正在开发用于治疗人类疾病，如癌症和糖尿病。这些药物在治疗人类癌症时是否只有特定的益处或有害作用将是一个深入研究的主题。在这里，我们回顾了AMPK研究的现状，重点是癌症，并讨论了尚未解决的上下文依赖功能的AMPK在人类癌症。
AMP kinase (AMPK) is an evolutionarily conserved enzyme required for adaptive responses to various physiological and pathological conditions. AMPK executes numerous cellular functions, some of which are often perceived at odds with each other. While AMPK is essential for embryonic growth and development, its full impact in adult tissues is revealed under stressful situations that organisms face in the real world. Conflicting reports about its cellular functions, particularly in cancer, are intriguing and a growing number of AMPK activators are being developed to treat human diseases such as cancer and diabetes. Whether these drugs will have only context-specific benefits or detrimental effects in the treatment of human cancer will be a subject of intense research. Here we review the current state of AMPK research with an emphasis on cancer and discuss the yet unresolved context-dependent functions of AMPK in human cancer.