Risk of lung cancer in relation to contiguous windows of endotoxin exposure among female textile workers in Shanghai
Risk of lung cancer in relation to contiguous windows of endotoxin exposure among female textile workers in Shanghai
复制标题
DOI：
10.1007/s10552-011-9812-x
复制
发表时间：
2011-10-01
影响因子：
2.3
通讯作者：
Eisen, Ellen A.
中科院分区：
文献类型：
--
作者：
Agalliu, Ilir;Costello, Sadie;Eisen, Ellen A.
Objective Exposure to endotoxin has been consistently associated with a reduced risk of lung cancer. However, there is a paucity of information regarding temporal aspects of this relationship. The objective of this study was to investigate the associations between contiguous windows of endotoxin exposure and risk of lung cancer.Methods Data were reanalyzed from a case-cohort study (602 cases, 3,038 subcohort) of female textile workers in Shanghai, China. Cumulative endotoxin exposure was partitioned into two windows: >= 20 and = 20 years before risk (p trend = 0.02). Women in the highest two categories of cumulative exposures had hazard ratios of 0.78 (95% CI 0.60-1.03) and 0.77 (95% CI 0.58-1.02) for lung cancer, respectively, in comparison with unexposed textile workers. There was, however, a weaker association and not statistically significant between lung cancer and endotoxin exposure accumulated in the more recent window (
