Association between Thalamocortical Functional Connectivity Abnormalities and Cognitive Deficits in Schizophrenia
Association between Thalamocortical Functional Connectivity Abnormalities and Cognitive Deficits in Schizophrenia
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丘脑皮质功能连接异常与精神分裂症认知缺陷之间的关联
DOI：
10.1038/s41598-019-39367-z
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发表时间：
2019-02-27
影响因子：
4.6
通讯作者：
Wang, Lubin
中科院分区：
文献类型：
--
作者：
Chen, Pinhong;Ye, Enmao;Wang, Lubin
认知缺陷被认为是精神分裂症的核心组成部分，并可能预测功能结果。然而，神经心理障碍的神经基础仍有待充分阐明。我们的研究使用了来自公共静息状态fMRI数据库的59名精神分裂症患者和72名健康对照的数据。改善精神分裂症认知的测量和治疗研究(Matrics)电池用于测量精神分裂症患者的认知能力缺陷。通过丘脑皮质网络活动与7个认知域得分的线性回归分析，探讨精神分裂症认知障碍的神经相关因素。我们证实了精神分裂症患者前额叶-丘脑连接减少和感觉-运动-丘脑连接增加的组合。相关分析显示，精神分裂症患者双侧中央前、后回丘脑功能连通性与注意/警觉性、加工速度呈负相关(Pearson‘s r≤ −0.443，p≤ 0.042，FWE校正)，与阴性症状呈正相关(Pearson’s r≥ 0.375，p≤ 0.003，FWE校正)；(2)右侧小脑丘脑功能连通性与加工速度呈正相关(Pearson‘s r= 0.388，p= 0.388，FWE校正)。我们的研究表明，丘脑与感觉运动区的过度连接与认知缺陷的严重程度和临床症状有关，并扩大了我们对精神分裂症中“认知障碍”的神经基础的理解。
Cognitive deficits are considered a core component of schizophrenia and may predict functional outcome. However, the neural underpinnings of neuropsychological impairment remain to be fully elucidated. Data of 59 schizophrenia patients and 72 healthy controls from a public resting-state fMRI database was employed in our study. Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Battery was used to measure deficits of cognitive abilities in schizophrenia. Neural correlates of cognitive deficits in schizophrenia were examined by linear regression analysis of the thalamocortical network activity with scores of seven cognitive domains. We confirmed the combination of reduced prefrontal-thalamic connectivity and increased sensorimotor-thalamic connectivity in patients with schizophrenia. Correlation analysis with cognition revealed that in schizophrenia (1) the thalamic functional connectivity in the bilateral pre- and postcentral gyri was negatively correlated with attention/vigilance and speed of processing (Pearson’sr≤ −0.443,p≤ 0.042, FWE corrected), and positively correlated with patients’ negative symptoms (Pearson’sr≥ 0.375,p≤ 0.003, FWE corrected); (2) the thalamic functional connectivity in the right cerebellum was positively correlated with speed of processing (Pearson’sr= 0.388,p= 0.01, FWE corrected). Our study demonstrates that thalamic hyperconnectivity with sensorimotor areas is related to the severity of cognitive deficits and clinical symptoms, and extends our understanding of the neural underpinnings of “cognitive dysmetria” in schizophrenia.