Selection of adenoid cystic carcinoma cell clone highly metastatic to the lung: An experimental study
Selection of adenoid cystic carcinoma cell clone highly metastatic to the lung: An experimental study
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DOI：
10.1016/s0901-5027(05)80830-6
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发表时间：
1997-04-01
影响因子：
2.4
通讯作者：
Zhou, XAJA
中科院分区：
文献类型：
--
作者：
Guan, XF;Qiu, WL;Zhou, XAJA
肺转移在腺样囊性癌（ACC）患者中非常常见，本研究的目的是建立一个模型用于ACC转移机制和抗转移程序的实验研究。经过5次体内重复筛选，结合体外克隆技术和血小板聚集活性分析，从ACC细胞系（Acc-2）中筛选出具有高度肺转移性的克隆（Acc-M）。 Acc-M 和 Acc-2 细胞系的转移率为 96%，而 Acc-M 和 Acc-2 细胞系的转移率为 18%。转移率和转移肺重量与血小板聚集活性呈正相关。本研究对于 ACC 转移机制的研究可能很重要。
Lung metastasis is very common in patients with adenoid cystic carcinoma (ACC), The purpose of the present study is to establish a model for an experimental study of ACC metastatic mechanisms and antimetastatic procedures. After five repeated selections in vivo, combined with an in vitro cloning technique and analysis of platelet aggregation activity, a clone (Acc-M) highly metastatic to the lung was selected from an ACC cell line (Acc-2). The metastatic rate was 96% vs 18% for Acc-M and the Acc-2 cell line. The metastatic rate and the weight of the lung with metastases correlated positively with platelet aggregation activity. The present study might be important for research into mechanisms of ACC metastases.