Evaluation of Dry Eye With Videokeratographer Using a Newly Developed
Evaluation of Dry Eye With Videokeratographer Using a Newly Developed
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DOI：
10.1016/j.ajo.2023.03.023
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发表时间：
2023-05-04
影响因子：
4.2
通讯作者：
Sotozono, Chie
中科院分区：
文献类型：
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作者：
Kusada, Natsuki;Yokoi, Norihiko;Sotozono, Chie
中心点目的：分析一种新开发的定量评估Meyer环(MR)图像干扰的指标的有效性，并评价其在干眼(DE)临床评估中的作用。中心点设计：横断面研究。中心点方法：79例(79眼)DE患者，男10例，女69例，平均年龄62.7岁。通过视频角膜成像仪获得MR图像后，量化环上多个点的模糊程度，将整个角膜的总值定义为扰动值(DV)。单因素和多因素分析总DV(TDV；睁眼后5秒DV之和)与12个DE症状、干眼相关生活质量评分(DEQS)、泪半月板半径(Mm)、泪膜(TF)脂层铺展分级(SG；1~5级，1=最好)、TF无创破裂时间(NIBUT，秒)、荧光素破裂时间(FBUT，秒)、角膜上皮损伤评分(CEDS；最大15分)、结膜上皮损伤评分(CjEDS；最大6分)和Schirmer 1测试值(Mm)的相关性。结果：各DE症状及DEQS与TDV无显著相关性，而与SG、NIBUT、FBUT、CEDS、CjEDS呈显著正相关(r分别为0.56、-0.45、-0.45、0.72、0.62，P均<0.01)。TDV2334+(412.1 x CEDS)-(302.0 x fBUT)(R2=0.593，P&t；0.0001)。中心点结论：我们新开发的指标DV，反映了TF的动态和稳定性以及角膜结膜上皮损伤，可能有助于定量诊断DE眼表异常。2023；252：135-146。(C)2023 Elsevier Inc.保留所有权利。)
center dot PURPOSE: To analyze the effectiveness of a newly de-veloped indicator that quantitatively assesses disturbance in Meyer-ring (MR) images obtained via videokeratogra-pher and assess its usefulness for the clinical evaluation of dry eye (DE). center dot DESIGN: Cross-sectional study. center dot METHODS: This study involved 79 eyes of 79 DE pa-tients (10 males and 69 females; mean age: 62.7 years). After MR images were obtained via videokeratographer, the degree of blur was quantified at multiple points on the ring, with the total value across the cornea being defined as the disturbance value (DV). Correlations between to-tal DV (TDV; the sum of DV for 5 seconds after eye opening) and 12 DE symptoms, Dry Eye-Related Qual-ity of Life Score (DEQS), tear meniscus radius (mm), tear film (TF) lipid-layer spread grade (SG; grades 1-5, 1 = best), TF noninvasive breakup time (NIBUT, seconds), fluorescein breakup time (FBUT, seconds), corneal epithelial damage score (CEDS; maximum: 15 points), conjunctival epithelial damage score (CjEDS; maximum: 6 points), and Schirmer 1 test value (mm) were analyzed via univariate and multivariate analyses. center dot RESULTS: No significant correlations were found be-tween TDV and each DE symptom or DEQS, yet sig-nificant correlations were found between TDV and SG, NIBUT, FBUT, CEDS, and CjEDS ( r = 0.56, -0.45, -0.45, 0.72, and 0.62, respectively, all P < .01). TDV was found to be described as 2334 + (412.1 x CEDS) - (302.0 x FBUT) ( R 2 = 0.593, P < .0001). center dot CONCLUSIONS: Our newly developed indicator, DV, re-flecting TF dynamics and stability and corneoconjuncti-val epithelial damage, may be useful for quantitatively as-sessing DE ocular-surface abnormalities. (Am J Oph-thalmol 2023;252: 135-146. (c) 2023 Elsevier Inc. All rights reserved.)