Roles of microRNAs in the resistance to platinum based chemotherapy in the non-small cell lung cancer.

Roles of microRNAs in the resistance to platinum based chemotherapy in the non-small cell lung cancer.
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microRNA在非小细胞肺癌铂类化疗耐药中的作用

DOI:
10.7150/jca.21267
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发表时间:
2017
期刊:
影响因子:
3.9
通讯作者:
Fan S
Fan S
中科院分区:
医学3区
文献类型:
--
作者:
Zang H;Peng J;Wang W;Fan S

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以铂为基础的辅助化疗可提高肺肿瘤患者的生存率,特别是非小细胞肺癌(NSCLC)。但NSCLC患者的耐药困境一直困扰着我们。在铂化疗耐药和敏感的NSCLC细胞中,microrna的谱存在差异。在铂耐药病例中,对microrna及其靶点的研究,为非小细胞肺癌患者铂基化疗提供了新的思路。因此,本文将从上皮-间质转化(Epithelial-mesenchymal transition, EMT)、细胞增殖和凋亡以及microrna在顺铂(CDDP)和卡铂(CBP)耐药中的作用三个方面进行综述。
Platinum-based adjuvant chemotherapy improves survival among patients with lung tumors, in particular non-small cell lung cancer (NSCLC). But the predicament of drug resistance in NSCLC patients is frustrating us. The profiles of microRNAs are different between platinum chemotherapy resistant and sensitive NSCLC cells. Researches regarding microRNAs and their targets, in platinum drug resistant cases, illuminate novel ideals for platinum-based chemotherapy for NSCLC patients. Therefore, in this review we will focus on three aspects: Epithelial-mesenchymal transition (EMT), cell proliferation and apoptosis, and the roles of microRNAs in cisplatin (CDDP) and carboplatin (CBP) resistance.
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