The endothelium but not the syncytiotrophoblast of human placenta expresses caveolae
The endothelium but not the syncytiotrophoblast of human placenta expresses caveolae
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DOI：
10.1053/plac.2002.0847
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发表时间：
2002-09-01
期刊：
影响因子：
3.8
通讯作者：
Robinson, JM
中科院分区：
文献类型：
--
作者：
Lyden, TW;Anderson, CL;Robinson, JM
人类胎盘是一个复杂的专门化结构，在母体和胎儿循环之间调节分子、离子和气体的交换。我们研究了小窝/小窝蛋白在胎盘中的分布和表达。应用免疫化学、免疫细胞化学和超微结构方法，我们发现胎盘表达小窝蛋白-1和小窝蛋白-2，这是小窝的标志蛋白。这些蛋白和小凹在胎盘毛细血管内皮细胞、大血管内皮细胞和血管内皮细胞高水平表达。此外，胎盘结缔组织含量高的区域的成纤维细胞也表达小窝蛋白。然而，我们无法在合体滋养层或细胞滋养层中检测到这些蛋白质或小凹样结构。这些结果对进一步了解胎盘生物学和小窝蛋白在该器官细胞调节中的作用具有重要意义。(C)2002爱思唯尔科学有限公司。保留所有权利。
The human placenta is a complex specialized structure that mediates the interchange of molecules, ions, and gases between maternal and foetal circulation. We have investigated the distribution and expression of caveolae/caveolin in the placenta. Using immunochemical, immunocytochemical, and ultrastructural methods, we show that the placenta expresses caveolin-1 and caveolin-2, which are marker proteins for caveolae. These proteins and caveolae were expressed at high levels in cndothelium of placental capillaries and in endothelial and smooth muscle cells of larger vessels. In addition, fibroblasts in areas of the placenta with high connective tissue content also expressed caveolin. However, we were unable to detect these proteins or caveolae-like structures in the syncvtiotrophoblast layer or in cytotrophoblasts. These results have important implications for further understanding placental biology and for the role of caveolac in cell regulation in this organ. (C) 2002 Elsevier Science Ltd. All rights reserved.