Contractile effects of endothelin 1 and endothelin 3 on myometrium and small intramyometrial arteries of pregnant women at term.
Contractile effects of endothelin 1 and endothelin 3 on myometrium and small intramyometrial arteries of pregnant women at term.
复制标题
内皮素1和内皮素3对足月孕妇子宫肌层和肌内小动脉的收缩作用。
DOI：
10.1159/000292619
复制
发表时间：
1993
影响因子：
2.1
通讯作者：
B. Lindblom
中科院分区：
文献类型：
--
作者：
K. Wolff;H. Nisell;A. Modin;J. Lundberg;N. Lunell;B. Lindblom
本研究旨在探讨内皮素1（ET-1）和内皮素3（ET-3）对足月妊娠妇女子宫肌内动脉和子宫肌组织的影响。分离在剖宫产时获得的子宫肌层小动脉段（外径100-500微米），并固定在组织室中。将ET-1和ET-3对等长收缩张力的作用与去甲肾上腺素的作用进行比较。在类似的子宫肌条实验中，研究了ET-1和ET-3与催产素的作用。ET-1和ET-3均能引起动脉和肌条的收缩，其中ET-1作用最强。ET-1的反应比参比化合物的作用更强，即去甲肾上腺素对子宫肌层动脉的作用和催产素对子宫肌层的作用。结论：内皮素是妊娠妇女子宫肌层动脉的强收缩剂，具有强的催产作用。特别是，ET-1可能参与子宫肌层收缩力和/或子宫胎盘血流的调节。
This in vitro study was undertaken to investigate the effects of endothelin 1 (ET-1) and endothelin 3 (ET-3) on intramyometrial arteries and myometrial tissue of the uterus from pregnant women at term. Segments of small myometrial arteries (outer diameter 100-500 microns) obtained at cesarean section were isolated and mounted in tissue chambers. The effect of ET-1 and ET-3 on isometric tension was compared with the action of noradrenaline. In similar experiments on myometrial strips, the effect of ET-1 and ET-3 was studied in comparison with oxytocin. ET-1 and ET-3 both produced contractions of arteries and myometrial strips, ET-1 being the most potent. The response of ET-1 was more powerful than the effect of the reference compounds, i.e. noradrenaline with regard to myometrial arteries and oxytocin with regard to the myometrium. It is concluded that endothelins are powerful constrictors of myometrial arteries from pregnant women and possess strong oxytocic effects. In particular, ET-1 could be involved in the regulation of myometrial contractility and/or uteroplacental blood flow.