ON NARCOLEPSY: I. FAMILIAL NARCOLEPSEY
ON NARCOLEPSY: I. FAMILIAL NARCOLEPSEY
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关于发作性睡病：I. 家族性发作性睡病
DOI：
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发表时间：
1942
期刊：
影响因子：
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通讯作者：
G. Magnussen
中科院分区：
文献类型：
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作者：
E. Krabbe;G. Magnussen
我们对嗜睡症的认识是相对较新的，因为这种综合征首先由Wesfpha于1877年描述，并由Gelineau于1880年命名为嗜睡症。它的主要特征是睡眠的siiddeii攻击或普遍的紧张性丧失的外观。个体患者可能不会有任何一种发作，或者仅仅是其中一种，或者他们可能在另一种发作之前几年一直忍受一种发作。大多数患阵发性癫痫发作的病人是完全正常的。因此，他们中的许多人（我不认为他们患有任何真实的疾病，也不寻求医疗建议，直到攻击变得过于严重。此外，似乎有几位医生没有把发作性睡病的临床情况记在心里，所以很可能有很多病例从未被诊断出来。因此，这里要提到的家庭中的两个病例是在这些病人死亡后才确定的，第三个病例尽管反复进行了医疗检查，但以前一直没有被发现。然而，一旦认识到无睡综合征，它就提出了各种有趣的问题，尤其是在致命事件的情况下。这些情况是，进一步，相当罕见，我们将在这里描述一个家庭，其中四个同胞患有fraom嗜睡症。这些病例值得关注，因为发作性睡病合并内分泌紊乱和心脏现象。最后，四个兄弟姐妹中的两个死在了...
Our knowledge of narrolepsy is of a relatively recent date, as this syndrorne was first described by Wesfpha l in 1877, and named narcolepsy by Gelineau ill 1880. It is primarily characterized by the appearance of siiddeii attacks of sleep or universal loss of tonus. The individual patients niay have either kind of attack or mewly one of them, or they may be siibject to one kind of attack for years before the other sets in. Most of the patients suffering froni nai*coleptic attacks are othwwise perfectly norural. Hence triany of them (lo not think they are suffering from any real disease and seek no medical advice before the attacks become excessively severe. It would seem, nioreover, that several physicians fail to keep the clinical picture of narcolepsy in mind, so that very likely a good many cases have never been diagnosed. Thus, two of the cases in the family to be mentioned here were ascertained only after these patients had died, and a third case had not been recognized before, in spite of repeated medical examination. Once the niircoleptic syndrome is recognized, however, i t presents various interesting problems, not least in cases of fatnilial occurrence. These cases being, further, fairly rare, we shall here describe a family, in which four sibs were suffering fraom narcolepsy. These cases are of additional interest because the narcolepsy was here combined with endocrine disturbances and cardiac pheiiomena. I'inally, two of the four sibs died pre-