Corneal hydration control in Fuchs' dystrophy.
Corneal hydration control in Fuchs' dystrophy.
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发表时间：
1989-05
影响因子：
4.4
通讯作者：
Robert D. Mandell;Kenneth A. Poise;Richard J. Drond;Dovid Vasrine;David Demarrini;R. Flom
中科院分区：
文献类型：
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作者：
Robert D. Mandell;Kenneth A. Poise;Richard J. Drond;Dovid Vasrine;David Demarrini;R. Flom
通过测量缺氧或过夜睡眠后引起的肿胀的角膜厚度恢复，在22名Fuchs营养不良患者和8名年龄相似的无疾病受试者中测试角膜水合控制。采用改进的光学厚度计和两种测试方法提高了测量精度，并用耦合指数模型进行了分析。我们已经确定了从角膜肿胀中恢复的三个参数，这些参数可用于描述水合控制：每小时回收率（Fuchs平均25.4%，正常34.2%），角膜厚度恢复95%的时间（Fuchs的平均值为10.2小时，正常人为7.1小时）和睁眼稳态厚度（Fuchs的平均值为562微米，正常人为537微米）。PRPH为17.1%/hr被确定为最小值，低于该值，角膜在一整天内无法恢复其睁眼稳态，并接近失代偿。我们的测试程序量化了角膜水合控制机制，并可提供内皮功能测试，可用于监测Fuchs病的进展并指导角膜手术相关决策。
Corneal hydration control was tested in 22 patients with Fuchs' dystrophy, and eight subjects of similar age without the disease, by measuring the corneal thickness recovery from swelling induced by hypoxia or following overnight sleep. Measurement precision was enhanced by using a modified optical pachometer and conducting two test procedures which were analyzed by a coupled exponential model. We have identified three parameters of the recovery from corneal swelling which may be used to describe hydration control: percent recovery per hour (PRPH) (mean 25.4% for Fuchs' and 34.2% for normals), time for 95% of corneal thickness recovery (mean 10.2 hr for Fuchs' and 7.1 hr for normals), and the open-eye steady-state thickness (mean 562 microns for Fuchs' and 537 microns for normals.) A PRPH of 17.1%/hr was identified as the minimum below which the cornea could not regain its open-eye steady state during the entire day and approaches decompensation. Our test procedure quantifies the corneal hydration control mechanism and may provide a test of endothelial function which can be used to monitor the progression of Fuchs' disease and guide decisions related to corneal surgery.