Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study
Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study
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DOI：
10.1186/s12886-019-1054-9
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发表时间：
2019-02-15
影响因子：
2
通讯作者：
Prata, Tiago S.
中科院分区：
文献类型：
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作者：
Lopes, Flavio S.;Matsubara, Igor;Prata, Tiago S.
BackgroundTo investigate structural and functional correlations in glaucoma patients using enhanced depth imaging spectral-domain optical coherence tomography（EDI OCT）-derived parameters.MethodsWe prospectively enrolled healthy participants and aerocomatous patients with a wide range of disease stages.所有参与者均接受视野（VF）测试（SITA - Standard 24-2; Carl Zeiss Meditec，都柏林，CA）和EDI OCT成像（Spectralis; Heidelberg Engineering Co.，海德堡，德国）。由两名不了解患者临床数据的经验丰富的检查者在连续垂直EDI OCT B扫描上测量以下视神经乳头参数：筛板（LC）厚度和面积、前板神经组织厚度和面积、前LC深度、布鲁赫膜开口（BMO）和平均值、上级和下级BMO最小边缘宽度（BMO-MRW）。只考虑高质量的图像，当双眼都合格时，随机选择一只进行分析。散点图构建调查每个解剖参数和患者的VF状态（VF指数[VFI]值的基础上）之间的相关性。ResultsA共73例患者的73只眼。所有评价的EDI OCT参数在青光眼和对照眼之间存在显著差异（P0.045）。二次分析中，根据VF平均偏差指数值将昏迷患者分为3组（轻度[G1; >-6dB]，中度[G2; -6至-12dB]和晚期[G3;
BackgroundTo investigate structural and functional correlations in glaucoma patients using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT)-derived parameters.MethodsWe prospectively enrolled healthy participants and glaucomatous patients with a wide range of disease stages. All participants underwent visual field (VF) testing (SITA - Standard 24-2; Carl Zeiss Meditec, Dublin, CA) and EDI OCT imaging (Spectralis; Heidelberg Engineering Co., Heidelberg, Germany). The following optic nerve head parameters were measured on serial vertical EDI OCT B-scans by two experienced examiners masked to patients clinical data: lamina cribrosa (LC) thickness and area, prelaminar neural tissue thickness and area, anterior LC depth, Bruch's membrane opening (BMO) and average, superior, and inferior BMO-minimum rim width (BMO-MRW). Only good quality images were considered, and whenever both eyes were eligible, one was randomly selected for analysis. Scatter plots were constructed to investigate correlations between each anatomic parameter and patient's VF status (based on VF index [VFI] values).ResultsA total of 73 eyes of 73 patients were included. All EDI OCT parameters evaluated differed significantly between glaucomatous and control eyes (P0.045). A secondary analysis, in which glaucomatous patients were divided according to VF mean deviation index values into 3 groups (mild [G1; >-6dB], moderate [G2; -6 to -12dB] and advanced [G3;