Reversal of diminished inhibitory sensory gating in cocaine addicts by a nicotinic cholinergic mechanism
Reversal of diminished inhibitory sensory gating in cocaine addicts by a nicotinic cholinergic mechanism
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DOI：
10.1016/s0893-133x(00)00242-6
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发表时间：
2001-06-01
影响因子：
7.6
通讯作者：
Freedman, R
中科院分区：
文献类型：
--
作者：
Adler, LE;Olincy, A;Freedman, R
可卡因成瘾和其他兴奋剂滥用一样，会产生精神病症状。尽管这些症状的严重程度通常为中度至轻度，但总体结局较差。最近的研究表明，减少烟碱胆碱能神经传递作为一种机制的生理缺陷发现精神分裂症，失败的听觉感觉抑制。抑制性感觉门控减弱也发生在可卡因成瘾者身上，可能是因为他们增加了儿茶酚胺神经传递，阻断了抑制作用。在本研究中，11名可卡因成瘾者在戒毒的第一周进行了电生理记录，然后在双盲安慰剂对照交叉设计中评估了6 mg尼古丁口香糖的效果。10天后重复测试。尼古丁治疗，但不是安慰剂，在两个测试日短暂逆转了抑制异常。虽然尼古丁本身可能不是一种理想的治疗剂，因为尼古丁受体的脱敏限制了其作用的时间过程，但该研究确定了一个以前未开发的治疗靶点，用于可卡因添加的神经精神后遗症的新药开发。(C)2001年美国神经精神药理学学会。出版社：Elsevier Science Inc.
Cocaine addiction, as with other stimulant abuse, produces psychotic symptoms. Although often moderate to mild in severity, these symptoms are, nevertheless, associated with poorer over-all outcome. Recent studies suggest diminished nicotinic cholinergic neurotransmission as a mechanism of a physiological deficit found in schizophrenia, failure of auditory sensory inhibition. Diminished inhibitory sensory gating also occurs in cocaine addicts, probably because of their increased catecholamingeric neurotransmission, which blocks the inhibition. In the present study, 11 cocaine addicts in the first week of detoxification were recorded electrophysiologically, after which the effects of 6 mg of nicotine gum, were assessed in a double-blind placebo-controlled crossover design. The test was repeated 10 days later. Treatment with nicotine, but not placebo, briefly reversed the inhibitory abnormality on both test days. Although nicotine itself may not be a desirable therapeutic agent, because desensitization of nicotinic receptors limits the time course of its effect, the study identifies a previously unexploited therapeutic target for new drug development of the neuropsychiatric sequelae of cocaine addition. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.