Deoxyglucose lumped constant estimated in a transplanted rat astrocytic glioma by the hexose utilization index.
Deoxyglucose lumped constant estimated in a transplanted rat astrocytic glioma by the hexose utilization index.
复制标题
通过己糖利用指数估计移植的大鼠星形细胞胶质瘤中的脱氧葡萄糖集总常数。
DOI：
10.1038/jcbfm.1990.34
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Woods,SD
中科院分区：
文献类型：
--
作者：
Spence,AM;Graham,MM;Muzi,M;Abbott,GL;Krohn,KA;Kapoor,R;Woods,SD
在移植大鼠胶质瘤和正常大鼠脑中，用脱氧葡萄糖（DG）法计算区域葡萄糖（glc）代谢率的集总常数（LC）。首先，在静脉注射[3H]DG和[14C]葡萄糖后，分别在1.5、3.0和4.5 min测量右半球胶质瘤植入物和未受损伤的对侧半球的己糖利用指数（HUI）。此时胶质瘤HUI值分别为0.639、0.732、0.712，左半球坐标值分别为0.432、0.449、0.418。其次，测定胶质瘤植入物中DG和葡萄糖的分布体积分别为0.436和0.235，左半球为0.402和0.237。第三，同时在颈动脉内注射[3H]DG和[14C]葡萄糖后，胶质瘤移植物的比值为1.1，左半球为1.3。根据这些HUI、分布体积和k1比值，估计该大鼠胶质瘤的LC比左半球LC高2.1倍（p< 0.02）。这些结果表明，用正常脑LC测量脑肿瘤CMRglc可能会显著高估真实肿瘤CMRglc。
The lumped constant (LC) for calculating the regional glucose (glc) metabolic rate by the deoxyglucose (DG) method was estimated in a transplanted rat glioma and normal rat brain. First, the hexose utilization index (HUI) was measured at 1.5, 3.0, and 4.5 min in right hemisphere glioma implants and uninvolved contralateral hemisphere following bolus intravenous injections of [3H]DG and [14C]glucose. At these times, the glioma HUI values were 0.639, 0.732, and 0.712, respectively, and the coordinate left hemisphere values were 0.432, 0.449, and 0.418. Second, the volumes of distribution of DG and glucose were determined to be 0.436 and 0.235 in glioma implants and 0.402 and 0.237 in left hemisphere, respectively. Third, following simultaneous intracarotid injections of [3H]DG and [14C]glucose, the ratioK*1/K1was 1.1 in glioma grafts and 1.3 in left hemisphere. With these values for HUI, volume of distribution, andK1ratio, the LC in this rat glioma was estimated to be 2.1 times higher than the left hemisphere LC (p< 0.02). These results suggest that measurement of brain tumor CMRglcusing a normal brain LC may significantly overestimate the true tumor CMRglc.
登录
查看更多内容
影响因子：
2.7
作者：
M. Viergever;P. Elsen;R. Stokking
通讯作者：
R. Stokking
医学图像解读中的视觉线索
影响因子：
2.4
作者：
H. Kundel
通讯作者：
H. Kundel
MR和PET数据集成三维显示的体绘制技术
DOI：
10.1007/978-3-642-84211-5_24
发表时间：
1990
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Xiaoping Hu;K. K. Tan;D. Levin;C. Pelizzari;George T. Y. Chen
通讯作者：
George T. Y. Chen
影响因子：
19.7
作者：
R. Robb
通讯作者：
R. Robb
标记引导的大脑多模态匹配
影响因子：
5.9
作者：
P. Elsen;M. Viergever
通讯作者：
M. Viergever