AMPK in Neurodegenerative Diseases
AMPK in Neurodegenerative Diseases
复制标题
DOI：
10.1007/978-3-319-43589-3_7
复制
发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Vingtdeux, Valerie
中科院分区：
文献类型：
--
作者：
Domise, Manon;Vingtdeux, Valerie
阿尔茨海默病、帕金森病、亨廷顿病和肌萎缩性侧索硬化症都是神经退行性疾病，其特征是神经细胞的进行性退化，最终导致痴呆。虽然这些疾病影响不同的神经元群并呈现不同的临床特征，但它们具有一些共同的特征和信号通路。特别是，能量代谢缺陷、氧化应激和兴奋性毒性通常被描述为可能与amp激活的蛋白激酶（AMPK）解除管制相关。AMPK是一种主要的能量传感器，据报道，在这些神经退行性疾病患者的大脑中，AMPK被过度激活。虽然AMPK在这些疾病中的确切作用仍有待明确，但一些研究报道了AMPK在参与这些疾病进展的各种信号通路中的含义。在本章中，我们回顾了目前关于AMPK参与这些疾病发展的文献，并讨论了所涉及的常见途径。
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are neurodegenerative disorders that are characterized by a progressive degeneration of nerve cells eventually leading to dementia. While these diseases affect different neuronal populations and present distinct clinical features, they share in common several features and signaling pathways. In particular, energy metabolism defects, oxidative stress, and excitotoxicity are commonly described and might be correlated with AMP-activated protein kinase (AMPK) deregulation. AMPK is a master energy sensor which was reported to be overactivated in the brain of patients affected by these neurodegenerative disorders. While the exact role played by AMPK in these diseases remains to be clearly established, several studies reported the implication of AMPK in various signaling pathways that are involved in these diseases' progression. In this chapter, we review the current literature regarding the involvement of AMPK in the development of these diseases and discuss the common pathways involved.