Clinical Dementia Rating training and reliability in multicenter studies: The Alzheimer's Disease Cooperative Study experience
Clinical Dementia Rating training and reliability in multicenter studies: The Alzheimer's Disease Cooperative Study experience
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DOI：
10.1212/wnl.48.6.1508
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发表时间：
1997-06-01
期刊：
影响因子：
9.9
通讯作者：
Thal, LJ
中科院分区：
文献类型：
--
作者：
Morris, JC;Ernesto, C;Thal, LJ
痴呆症严重程度的全球评级越来越多地用于抗痴呆化合物的临床试验。此类评级具有临床相关性，但其在多中心环境中的可靠性尚未确定。为了评估全球量表临床痴呆评级 (CDR) 的可靠性，多中心阿尔茨海默病合作研究的 82 名研究人员参加了一项培训和可靠性协议，使用对阿尔茨海默病各个阶段的受试者进行录像评估。培训后，研究人员与“金标准”CDR 评分的总体一致性为 83%。这些结果表明，该培训协议有助于在痴呆严重程度分期方面建立良好的一致性水平，并且 CDR 可以被标准化为阿尔茨海默病多中心研究的临床全球规模。
Global ratings of dementia severity are used increasingly in clinical trials of antidementia compounds. Such ratings are clinically relevant, but their reliability in multicenter settings has not been determined. To evaluate the reliability of one global scale, the Clinical Dementia Rating (CDR), 82 investigators of the multicenter Alzheimer's Disease Cooperative Study participated in a training and relibility protocol using videotaped assessments of subjects in various stages of Alzheimer's disease, Following training, overall agreement of the investigators with ''gold standard'' CDR scores was 83%, These results indicate that the training protocol is useful for establishing good levels of agreement in staging dementia severity and that the CDR can be standardized as a clinical global scale for multicenter studies of Alzheimer's disease.