Comparison of visceral fat mass measurement by dual-X-ray absorptiometry and magnetic resonance imaging in a multiethnic cohort: the Dallas Heart Study.
Comparison of visceral fat mass measurement by dual-X-ray absorptiometry and magnetic resonance imaging in a multiethnic cohort: the Dallas Heart Study.
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DOI：
10.1038/nutd.2016.28
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发表时间：
2016-07-18
影响因子：
6.1
通讯作者：
Vega GL
中科院分区：
文献类型：
--
作者：
Neeland IJ;Grundy SM;Li X;Adams-Huet B;Vega GL
内脏脂肪组织（VAT）质量是肥胖心脏代谢并发症的危险因素，通常通过磁共振成像（MRI）测量，但这种方法在临床环境中不实用。相比之下，通过双X射线吸收法（DXA）测量VAT似乎可以规避MRI的局限性。在这项研究中，我们比较了达拉斯心脏研究（DHS）的大型多种族队列中通过MRI和DXA测量的VAT质量。大约2689名DHS参与者通过MRI和DXA进行了VAT的配对测量。进行性别分层分析，以评估DXA和MRI之间的相关性和一致性。使用自举法进行模型验证，并评估阅片者间变异性。队列的平均年龄为44岁，其中55%为女性，48%为黑人，75%为超重/肥胖参与者。回归分析显示DXA和MRI之间存在线性关系，女性R2=0.82（95%置信区间（CI）0.81-0.84），男性R2=0.86（95% CI 0.85-0.88）。方法间的平均差异为0.01 kg（雌性）和0.09 kg（雄性）。Bland-Altman分析显示，在较低VAT水平下，DXA与MRI相比倾向于适度低估VAT，而在较高VAT水平下，DXA与MRI相比倾向于高估VAT。按种族、体重指数状态、腰围和体脂分层的分析结果一致。在50个随机选择的扫描中，个体阅片者之间的相关性非常好（类间相关系数=0.997）。通过DXA进行的VAT质量定量在一个大的、多种族的、广泛的体脂范围内的队列中是准确和有效的。进一步的研究，包括一段时间内的重复评估，将有助于确定其长期适用性。
Visceral adipose tissue (VAT) mass, a risk factor for cardiometabolic complications of obesity, is usually measured by magnetic resonance imaging (MRI) but this method is not practical in a clinical setting. In contrast, measurement of VAT by dual-x-ray absorptiometry (DXA) appears to circumvent the limitations of MRI. In this study, we compared measurements of VAT mass by MRI and DXA in the large, multiethnic cohort of the Dallas Heart Study (DHS). About 2689 DHS participants underwent paired measurement of VAT by MRI and DXA. Sex-stratified analyses were performed to evaluate the correlation and agreement between DXA and MRI. Model validation was performed using bootstrapping and inter-reader variability was assessed. Mean age of the cohort was 44 years, with 55% female, 48% Black and 75% overweight/obese participants. Regression analysis showed a linear relationship between DXA and MRI with R2=0.82 (95% confidence interval (CI) 0.81–0.84) for females and R2=0.86 (95% CI 0.85–0.88) for males. Mean difference between methods was 0.01 kg for females and 0.09 kg for males. Bland–Altman analysis showed that DXA tended to modestly underestimate VAT compared with MRI at lower VAT levels and overestimate it compared with MRI at higher VAT levels. Results were consistent in analyses stratified by race, body mass index status, waist girth and body fat. Inter-individual reader correlation among 50 randomly selected scans was excellent (inter-class correlation coefficient=0.997). VAT mass quantification by DXA was both accurate and valid among a large, multiethnic cohort within a wide range of body fatness. Further studies including repeat assessments over time will help determine its long-term applicability.