A Rodent Model of Dynamic Facial Reanimation Using Functional Electrical Stimulation.
A Rodent Model of Dynamic Facial Reanimation Using Functional Electrical Stimulation.
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DOI：
10.3389/fnins.2017.00193
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发表时间：
2017
影响因子：
4.3
通讯作者：
Lucas TH
中科院分区：
文献类型：
--
作者：
Attiah MA;de Vries J;Richardson AG;Lucas TH
面瘫可能是一个毁灭性的条件，造成毁容面部下垂，言语不清，眼睛干燥，疤痕和失明。本研究探讨了定量啮齿动物模型中闭环功能性电刺激（FES）对麻痹面部肌肉复苏的效用。切断大鼠面神经的右侧颊支和下颌缘支，以选择性地单侧麻痹胡须肌。将微丝电极植入双侧面部肌肉组织中进行FES和肌电图（EMG）记录。在大鼠清醒和头部固定的情况下，用光学测微计跟踪双侧胡须轨迹。首先，肌电图和意志胡须运动之间的关系进行了量化的完整侧的脸。其次，在瘫痪侧量化FES对触须轨迹的影响。第三，进行了闭环实验，其中，在完整侧的EMG信号触发瘫痪侧的FES，以恢复对称的拂动。结果表明，一种新的在体内平台，开发控制策略的神经肌肉面部假体。
Facial paralysis can be a devastating condition, causing disfiguring facial droop, slurred speech, eye dryness, scarring and blindness. This study investigated the utility of closed-loop functional electric stimulation (FES) for reanimating paralyzed facial muscles in a quantitative rodent model. The right buccal and marginal mandibular branches of the rat facial nerve were transected for selective, unilateral paralysis of whisker muscles. Microwire electrodes were implanted bilaterally into the facial musculature for FES and electromyographic (EMG) recording. With the rats awake and head-fixed, whisker trajectories were tracked bilaterally with optical micrometers. First, the relationship between EMG and volitional whisker movement was quantified on the intact side of the face. Second, the effect of FES on whisker trajectories was quantified on the paralyzed side. Third, closed-loop experiments were performed in which the EMG signal on the intact side triggered FES on the paralyzed side to restore symmetric whisking. The results demonstrate a novel in vivo platform for developing control strategies for neuromuscular facial prostheses.