FUNCTIONING OXYPHIL CELL ADENOMA OF THE PARATHYROID-GLAND - A CLINICOPATHOLOGIC STUDY OF TEN PATIENTS WITH HYPERPARATHYROIDISM
FUNCTIONING OXYPHIL CELL ADENOMA OF THE PARATHYROID-GLAND - A CLINICOPATHOLOGIC STUDY OF TEN PATIENTS WITH HYPERPARATHYROIDISM
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DOI：
10.1016/s0046-8177(84)80306-8
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发表时间：
1984-01-01
期刊：
影响因子：
3.3
通讯作者：
WATSON, CG
中科院分区：
文献类型：
--
作者：
BEDETTI, CD;DEKKER, A;WATSON, CG
甲状旁腺腺瘤是原发性甲状旁腺功能亢进最常见的病因，多数为单发主细胞型。甲状旁腺腺瘤主要或完全由氧细胞组成是罕见的，以前被认为是无功能的。在160例经外科检查的原发性甲状旁腺功能亢进患者中，10例（6.25%）有嗜氧细胞类型的腺瘤。8名女性和2名男性的年龄范围为0.2-4.0 g（平均1.2 g）。腺瘤9例位于左颈，其余1例位于右颈。组织学上，肿瘤几乎完全由移行性和典型的嗜氧细胞组成。在每个病例中都发现了由主要细胞组成的残留甲状旁腺囊。电镜、磷钨酸-苏木精染色和细胞色素c氧化酶免疫过氧化物酶技术显示，嗜氧细胞中存在大量线粒体。所有患者在肿瘤切除后4个月-4年（平均23个月）血清钙水平正常。
Adenomas of the parathyroid gland, the majority of which are of the solitary chief cell type, are the most frequent cause of primary hyperparathyroidism. Parathyroidsm adenomas composed predominantly or exclusively of oxyphil cells are rare and were previously considered nonfunctioning. Among 160 consecutive patients with primary hyperparathyrodism who were explored surgically, 10 (6.25%) had adenomas of the oxyphil cell variety. The 8 women and 2 men in this series ranged in age from 0.2-4.0 g (average, 1.2 g). Of the adenomas, 9 were located in the left neck, while the remaining tumor was in the right neck. Histologically, the tumors were composed almost exclusively of transitional and typical oxyphil cells. A residual capsular parathyroid composed of chief cells was identified in each case. EM, phosphotungstic acid-hematoxylin staining, and the immunoperoxidase technique for cytochrome c oxidase showed the presence of numerous mitochondria in oxyphil cells. All patients had normal serum Ca levels 4 mo.-4 yr (average, 23 mo.) after removal of the neoplasms.