A novel role of oxytocin: Oxytocin-induced well-being in humans
A novel role of oxytocin: Oxytocin-induced well-being in humans
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DOI：
10.2142/biophysico.16.0_132
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发表时间：
2019-01-01
影响因子：
1.5
通讯作者：
Yoshioka, Tohru
中科院分区：
文献类型：
--
作者：
Ito, Etsuro;Shima, Rei;Yoshioka, Tohru
我们回顾了一种小分子催产素在躯体感觉器官的物理刺激、正念冥想、情绪和香味对人类的各种影响中的作用，然后提出了一个假设，即人类的复杂状态和行为，如幸福感、社会联系和情感行为，可以用催产素来解释。我们之前报道过催产素可以缓解疼痛，并描述了催产素在背角和/或背根神经节缓解关节和肌肉疼痛的可能性。在这篇文章中，我们将我们的研究目标从催产素的物理镇痛作用扩展到它的心理作用，以上调幸福感和下调压力和焦虑。为此，我们提出了一个“下丘脑-垂体-肾上腺（HPA）轴-催产素模型”来解释为什么正念冥想、安慰剂和香水可以减轻压力和焦虑，从而产生满足感。这一新提出的HPA轴-催产素在大脑中的模型也提供了一个目标，以解决有关情绪行为、学习和记忆以及过量食物摄入导致肥胖的其他问题，旨在促进健康生活。
We review the involvement of a small molecule, oxytocin, in various effects of physical stimulation of somatosensory organs, mindfulness meditation, emotion and fragrance on humans, and then propose a hypothesis that complex human states and behaviors, such as well-being, social bonding, and emotional behavior, are explained by oxytocin. We previously reported that oxytocin can induce pain relief and described the possibility how oxytocin in the dorsal horn and/or the dorsal root ganglion relieves joint and muscle pain. In the present article, we expand our research target from the physical analgesic effects of oxytocin to its psychologic effects to upregulate well-being and downregulate stress and anxiety. For this purpose, we propose a "hypothalamic-pituitary-adrenal (HPA) axis-oxytocin model" to explain why mindfulness meditation, placebo, and fragrance can reduce stress and anxiety, resulting in contentment. This new proposed model of HPA axis-oxytocin in the brain also provides a target to address other questions regarding emotional behaviors, learning and memory, and excess food intake leading to obesity, aimed at promoting a healthy life.