Modulatory influence of unsaturated fatty acids on the biology of tumour necrosis factor-alpha.
Modulatory influence of unsaturated fatty acids on the biology of tumour necrosis factor-alpha.
复制标题
不饱和脂肪酸对肿瘤坏死因子-α生物学的调节影响。
DOI：
--
复制
发表时间：
1995
影响因子：
3.9
通讯作者：
P. Tappia
中科院分区：
文献类型：
--
作者：
R. Grimble;P. Tappia
前言：细胞因子肿瘤坏死因子是多种分子中的一种，在诱导和调节炎症和免疫过程中发挥重要作用。与其他细胞因子一样，肿瘤坏死因子主要是免疫系统的产物；然而，内皮细胞也具有产生肿瘤坏死因子的能力。从生物学上讲，肿瘤坏死因子是一种触发剂，可以激活一系列细胞因子的产生。该分子在炎症和感染性介质的作用下迅速释放，并诱导产生广泛的细胞因子，包括白介素1和白介素6(IL-1和11，-6)，它与白介素1和白介素6有许多共同作用。这些包括发烧、自由基和急性期蛋白质的产生以及黏附分子的上调[1-31。肿瘤坏死因子可能通过诱导趋化因子IL-8来延长炎症过程[4]。肿瘤坏死因子可通过诱导IL-1，刺激IL-2和IL-4的产生，间接调节免疫事件。后两种细胞因子分别导致淋巴细胞增殖增加和免疫球蛋白类别转换[4]。除了作为炎症和免疫过程的早期效应者的重要作用外，肿瘤坏死因子在杀死真菌和一些病毒方面也很重要[S]。然而，过量的或生物学上不适当的肿瘤坏死因子的产生与病理事件密切相关。这些事件与脑性疟疾、内毒素休克、败血症和成人呼吸窘迫综合征的死亡密切相关，与一系列自身免疫性疾病的病理密切相关[11.这些疾病包括类风湿性关节炎、炎症性肠道疾病、牛皮癣
Introduction The cytokine tumour necrosis factor (TNF) is one of a diverse range of molecules that play a major part in inducing and modulating inflammatory and immune processes. TNF, in common with other cytokines, is predominantly a product of the immune system; however, endothelial cells also have the capabilty of its production. Biologically, TNF acts as a trigger that activates a cascade of cytokine production. The molecule is released rapidly in response to inflammatory and infective agents and induces production of a wide range of cytokines, including interleukins 1 and 6 (IL-1 and 11,-6) with which it has a number of actions in common. These include fever, free radical and acute phase protein production and up-regulation of adhesion molecules [ 1-31. TNF may prolong the inflammatory process by inducing the chemokine IL-8 [4]. TNF can indirectly modulate immunological events by induction of IL-1, which stimulates IL-2 and IL-4 production. The latter two cytokines result in increased lymphocyte proliferation and switching of immunoglobulin classes respectively [4]. In addition to its important role as an early effector in inflammatory and immune processes, TNF is important in the killing of fungi and a number of viruses [S]. However, excessive or biologically inappropriate TNF production is closely associated with pathological events. Such events have been closely linked with mortality from cerebral malaria, endotoxic shock, sepsis and adult respiratory distress syndrome, and with pathology in a wide range of autoimmune disorders [ 11. These include rheumatoid arthritis, inflammatory bowel disease, psoriasis