Fetal methylmercury exposure as measured by cord blood mercury concentrations in a mother-infant cohort in Hong Kong
Fetal methylmercury exposure as measured by cord blood mercury concentrations in a mother-infant cohort in Hong Kong
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DOI：
10.1016/j.envint.2006.08.002
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发表时间：
2007-01-01
影响因子：
11.8
通讯作者：
Lam, Christopher W. K.
中科院分区：
文献类型：
--
作者：
Fok, Tai F.;Lam, Hugh S.;Lam, Christopher W. K.
这项研究的目的是检查出生前暴露于甲基汞水平的香港新生儿被认为会增加神经毒性作用的风险，并检查受试者的特征，修改产前汞暴露的程度。1057套母亲和脐带血样本和96个随机选择的母亲头发样本中的汞浓度进行了测量。受试者特征通过问卷测量或收集。在收集的1057份脐带血样本中，只有21.6%的样本汞浓度低于29 nmol/L（5.8 μ g/L）。母亲头发中汞浓度的中位数为1.7 ppm。脐带血汞与母体血汞的几何平均比值为1.79：1。研究发现，孕妇食用鱼类和孕妇年龄的增加与脐带血汞浓度的增加有关。食用海鱼使脐带血汞浓度增加的幅度大于淡水鱼（5.09%/kg vs 2.86%/kg）。女婴、母亲饮酒和母亲身高增加与脐带血汞浓度降低有关。香港的孕妇食用大量鱼类，因此，她们的后代在产前大多暴露于中等高水平的汞。在这一人群中，孕妇应选择淡水鱼而不是海鱼，并限制鱼类消费。(c)2006爱思唯尔有限公司保留所有权利。
This study was designed to examine newborn infants in Hong Kong prenatally exposed to levels of methylmercury considered to increase risk of neurotoxic effects and to examine subject characteristics that modify the degree of prenatal mercury exposure. Mercury concentrations in 1057 sets of maternal and cord blood samples and 96 randomly selected maternal hair samples were measured. Subject characteristics were measured or collected by questionnaire. Of the 1057 cord blood samples collected only 21.6% had mercury concentrations less than 29 nmol/L (5.8 mu g/L). Median maternal hair mercury concentration was 1.7 ppm. The geometric mean cord to maternal blood mercury ratio was 1.79 to 1. Increasing maternal fish consumption and maternal age were found to be associated with increased cord blood mercury concentrations. Marine fish consumption increased cord blood mercury concentrations more than freshwater fish (5.09%/kg vs 2.86%/kg). Female babies, maternal alcohol consumption and increasing maternal height were associated with decreased cord blood mercury concentrations. Pregnant women in Hong Kong consume large amounts of fish and as a result, most of their offspring have been prenatally exposed to moderately high levels of mercury. In this population, pregnant women should choose freshwater over marine fish and limit fish consumption. (c) 2006 Elsevier Ltd. All rights reserved.