Consumption of added sugars and indicators of cardiovascular disease risk among US adolescents.
Consumption of added sugars and indicators of cardiovascular disease risk among US adolescents.
复制标题
美国青少年的添加糖和心血管疾病风险的指标。
DOI：
10.1161/circulationaha.110.972166
复制
发表时间：
2011-01-25
期刊：
影响因子：
37.8
通讯作者：
Vos MB
中科院分区：
文献类型：
--
作者：
Welsh JA;Sharma A;Cunningham SA;Vos MB
成人中碳水化合物和糖消耗量的增加与血脂异常有关。然而，高消费量的添加糖（热量甜味剂）对美国青少年心脏代谢风险的影响尚不清楚。这是一项在1999-2004年国家健康和营养调查（NHANES）中对2，252名美国青少年（13-18岁）进行的横断面研究。来自一次24小时召回的饮食数据与来自美国农业部MyPyramid等效数据库的添加糖含量数据合并。通过添加糖摄入水平（<10%、10- <15%、15- <20%、20- <25%、25- <30%和≥30%总能量）估计心脏代谢指标的多变量校正均值，并加权以代表美国青少年。添加糖的平均消耗量为每日能量摄入量的21.4%。校正后的平均高密度脂蛋白胆固醇（HDL）水平较低，最低消费者为1.38 mmol/L（95% CI：1.32，1.43），最高消费者为1.28 mmol/L（95%置信区间[CI]：1.23，1.33）（p趋势=0.007）。几何平均甘油三酯水平范围为0.79 mmol/L（95% CI：0.72，0.86）至0.89 mmol/L（95% CI：0.83，0.96）（p趋势=0.03），添加糖的消耗量更大。在超重/肥胖（体重指数≥ 85百分位数）人群中，HOMA-IR与添加糖呈正相关（p-线性趋势<0.001），最高消费者与最低消费者之间平均高78%（p<0.001）。在低密度脂蛋白、体重指数或血压方面未观察到显著趋势。在美国青少年中，添加糖的摄入量与心脏代谢风险呈正相关。需要长期研究来确定减少添加糖是否会改善这些参数，从而减少未来的心血管事件。
Increased carbohydrate and sugar consumption has been associated with dyslipidemia among adults. However, the effect of high consumption of added sugars (caloric sweeteners) on measures of cardiometabolic risk among US adolescents is unknown. This was a cross-sectional study of 2,252 US adolescents (13–18 y) in the National Health and Nutrition Examination Survey (NHANES) 1999–2004. Dietary data from one 24-hour recall were merged with added sugar content data from the USDA MyPyramid Equivalents Databases. Multivariate-adjusted means of cardiometabolic indicators were estimated by added sugar consumption level (<10%, 10– <15%, 15– <20%, 20– <25%, 25– <30%, and ≥30% total energy) and weighted to be representative of US adolescents. Mean consumption of added sugars was 21.4% of daily energy intake. Adjusted mean high-density lipoprotein cholesterol (HDL) levels were lower, 1.38 mmol/L (95% CI: 1.32, 1.43) among the lowest consumers to 1.28 mmol/L (95% confidence interval [CI]: 1.23, 1.33) among the highest (p-trend=0.007). Geometric mean triglyceride levels ranged from 0.79 mmol/L (95% CI: 0.72, 0.86) to 0.89 mmol/L (95% CI: 0.83, 0.96) (p-trend=0.03) with greater consumption of added sugars. Among those overweight/obese (≥85th percentile body-mass-index [BMI]), HOMA-IRs were positively associated with added sugars (p-linear trend<0.001), averaging 78% higher among the highest vs. the lowest consumers (p<0.001). No significant trends were seen with low-density lipoproteins, body-mass-index, or blood pressure. In US adolescents, consumption of added sugars is positively associated with measures of cardiometabolic risk. Long-term studies are needed to determine if reduction in added sugars will improve these parameters and, thereby decrease future cardiovascular events.