Survivin, a potential early predictor of tumor progression in the oral mucosa
Survivin, a potential early predictor of tumor progression in the oral mucosa
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DOI：
10.1177/154405910308201115
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发表时间：
2003-11-01
影响因子：
7.6
通讯作者：
Altieri, DC
中科院分区：
文献类型：
--
作者：
Lo Muzio, L;Pannone, G;Altieri, DC
Survivin是一种新近发现的凋亡抑制因子，在大多数肿瘤中选择性过表达。免疫组化被用来研究生存素作为口腔癌前病变和癌性病变恶变的早期预测因子的潜在作用。Survivin在30例口腔癌前病变中的表达率为33%，在16例口腔癌前病变中的表达率为94%。从这些癌前病变进展的肿瘤保留了广泛的生存素阳性（100%）。组平均值之间的变化具有高度统计学显著性（p < 0.001）。Survivin的表达与异型增生程度无明显相关性。细胞质/细胞核Survivin的高表达是口腔癌发生过程中的早期事件，并可能提供一个有用的工具，以确定癌前病变的进展为浸润性癌的风险较高。
Survivin is a recently described apoptosis inhibitor selectively over-expressed in most tumors. Immunohistochemistry was used to investigate a potential role of survivin as an early predictor of malignant transformation in precancerous and cancerous lesions of the oral cavity. Survivin was present in 10/30 cases (33%) of oral precancerous lesions without malignant progression, and in 15/16 cases (94%) of oral precancerous lesions evolved into full-blown squamous cell carcinoma. Tumors that progressed from these precancerous lesions retained widespread survivin positivity (100%). Variations among group means were highly statistically significant (p < 0.001). No significant correlation was found between survivin expression and the degree of dysplasia. High expression of cytoplasmic/nuclear survivin is an early event during oral carcinogenesis and may provide a useful tool for the identification of precancerous lesions at higher risk of progression into invasive carcinoma.