The effect of chronic psychological stress on corticosterone, plasma metabolites, and immune responsiveness in European starlings
The effect of chronic psychological stress on corticosterone, plasma metabolites, and immune responsiveness in European starlings
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DOI：
10.1016/j.ygcen.2007.06.016
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发表时间：
2007-10-01
影响因子：
2.7
通讯作者：
Romero, L. Michael
中科院分区：
文献类型：
--
作者：
Cyr, Nicole E.;Earle, Kristen;Romero, L. Michael
虽然在急性应激期间糖皮质激素浓度的增加被认为有助于动物在应激事件中生存，但糖皮质激素浓度的慢性变化会改变新陈代谢并导致疾病。我们研究了慢性心理应激对皮质酮（CORT），皮质酮结合球蛋白（CBG），葡萄糖，甘油三酯浓度以及免疫反应的T细胞有丝分裂原的挑战，欧洲椋鸟，普通。为了诱导慢性应激，我们使用了由5种应激源（大声广播、笼内敲击、笼内滚动、人声和袋约束）组成的慢性应激协议，以随机顺序施用30分钟，每天4次，持续18天。在整个慢性应激期间，总CORT下降，这与先前对椋鸟的研究相似。CBG容量并未随着慢性应激而发生显着变化，因此在慢性应激期间，游离CORT遵循与总CORT相同的衰减模式。尽管CORT释放调节的变化，白天的葡萄糖和甘油三酯浓度并没有改变慢性应激。此外，慢性应激和非应激鸟类的免疫反应是相似的。我们的研究结果，加上以前的研究使用类似的CSP在欧洲椋鸟，表明椋鸟生理抑制HPA轴在慢性心理应激，以避免病理慢性增强CORT浓度，如高血糖症和免疫功能受损。爱思唯尔公司出版
Although increases in glucocorticoid concentrations during acute stress are believed to help animals survive stressful events, chronic changes in glucocorticoid concentrations can alter metabolism and lead to disease. We studied the effect of chronic psychological stress on corticosterone (CORT), corticosterone binding globulin (CBG), glucose, and triglyceride concentrations as well as immune responsiveness to a T-cell mitogen challenge in European starlings, Sturnus vulgaris. To induce chronic stress we used a chronic stress protocol consisting of five stressors (loud radio, cage tapping, cage rolling, human voice, and bag restraint) administered in random order for 30 min for 4 times/day over 18 days. Total CORT decreased throughout the chronic stress period, which parallels a previous study with starlings. CBG capacity did not significantly change with chronic stress, thus free CORT followed the same pattern of attenuation as total CORT during chronic stress. Despite the change in regulation of CORT release, daytime glucose and triglyceride concentrations did not change with chronic stress. In addition, immune responsiveness in chronically stressed and unstressed birds was similar. Our results, together with a previous study using a similar CSP in European starlings, suggest that starlings physiologically dampen the HPA axis during chronic psychological stress to avoid pathology associated with chronically augmented CORT concentrations such as hyperglycemia and impaired immune function. Published by Elsevier Inc.