Neural representation of expected value in the adolescent brain
Neural representation of expected value in the adolescent brain
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DOI：
10.1073/pnas.1319762111
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发表时间：
2014-01-28
影响因子：
11.1
通讯作者：
Galvan, Adriana
中科院分区：
文献类型：
--
作者：
Barkley-Levenson, Emily;Galvan, Adriana
先前的研究表明，青少年的奖励系统是过度活跃的，但这一发现可能会被青少年对金钱的不同看法所混淆。为了解决这个问题，我们研究了客观价值表征的神经个体发生。青少年和成人参与者执行了一项金钱赌博任务，他们选择接受或拒绝不同期望值的赌博。相对于成年人，期望值的增加对青少年的赌博选择有更强的影响，这种影响与青少年腹侧纹状体的更大激活相平行。这种独特的青少年腹侧纹状体反应即使在接受行为匹配组后仍然存在。这些行为和神经数据表明，即使在客观价值和主观选择保持不变的情况下，可用选项的价值对青少年的选择比成人的选择有更大的影响。这项研究提供了进一步的证据，证明青少年奖励回路的过度激活可能是一种规范的个体发生转变，这是由于青少年大脑中更高的估值。
Previous work shows that the adolescent reward system is hyperactive, but this finding may be confounded by differences in how teens value money. To address this, we examined the neural ontogeny of objective value representation. Adolescent and adult participants performed a monetary gambling task in which they chose to accept or reject gambles of varying expected value. Increasing expected value had a stronger influence over gambling choices in adolescents relative to adults, an effect that was paralleled by greater activation in the ventral striatum in adolescents. This unique adolescent ventral striatum response remained even after matching groups on acceptance behavior. These behavioral and neural data suggest that the value of available options has a greater influence in adolescent versus adult choices, even when objective value and subjective choice are held constant. This research provides further evidence that hyperactivation of reward circuitry in adolescence may be a normative ontogenetic shift that is due to greater valuation in the adolescent brain.