Pioglitazone improves endothelial and adipose tissue dysfunction in pre-diabetic CAD subjects
Pioglitazone improves endothelial and adipose tissue dysfunction in pre-diabetic CAD subjects
复制标题
DOI：
10.1016/j.atherosclerosis.2010.12.021
复制
发表时间：
2011-03-01
期刊：
影响因子：
5.3
通讯作者：
Federici, Massimo
中科院分区：
文献类型：
--
作者：
Rizza, Stefano;Cardellini, Marina;Federici, Massimo
目的：研究吡格列酮对新发现的IGT患者CAD.Methods和design内皮和脂肪组织功能障碍的影响：参与者（n = 25）随机接受安慰剂或吡格列酮（30 mg/天）治疗12周。治疗前后，我们评估了内皮功能（血流介导的肱动脉扩张- FMD -），循环脂肪和炎症标志物（脂联素亚型，TNF-α，和高敏感性-CRP），和胰岛素敏感性（正常血糖高胰岛素钳夹）。相比之下，接受吡格列酮治疗的受试者（n = 13）的FMD有显著改善（10.8 ± 5.3 vs 13.3 ± 3.6%，p < 0.01），伴有高分子量脂联素（HMW-Ad）增加（1.7 +/- 1.2 vs 4.8 +/- 3.6 μ g/ml，p < 0.05）和TNF-α降低（4.3 +/- 1.9 vs 3.2 +/- 1.2 pg/ml，p < 0.05）与葡萄糖处置增加相关（4.8 +/- 1.9 vs 5.4 +/- 2.0mg kg（-1）min（-1），p < 0.05）。多元回归分析表明吡格列酮后HMW-Ad的增加预示FMD的增加。吡格列酮显著改善糖尿病前期CAD患者的内皮和脂肪组织功能障碍。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Objective: To investigate the effect of pioglitazone on endothelial and adipose tissue dysfunction in newly detected IGT patients with CAD.Methods and design: Participants (n = 25) were randomized to treatment with either placebo or pioglitazone (30 mg/day) for 12 weeks. Before and after treatment we evaluated endothelial function (flow-mediated dilation - FMD - of the brachial artery), circulating adipose and inflammatory markers (adiponectin isoforms, TNF-alpha, and high sensitivity-CRP), and insulin sensitivity (euglycemic hyper-insulinemic clamp).Results: No significant changes were observed in subjects (n = 12) treated with placebo. By contrast, subjects (n = 13) treated with pioglitazone had significant improvement in FMD (10.8 +/- 5.3 vs 13.3 +/- 3.6%, p < 0.01), accompanied by increased high molecular weight adiponectin (HMW-Ad) (1.7 +/- 1.2 vs 4.8 +/- 3.6 mu g/ml, p < 0.05) and decreased TNF-alpha (4.3 +/- 1.9 vs 3.2 +/- 1.2 pg/ml, p < 0.05) associated to an increased glucose disposal (4.8 +/- 1.9 vs 5.4 +/- 2.0mg kg(-1) min(-1), p < 0.05).A multiple regression analysis indicated that increasing of HMW-Ad after pioglitazone predicted increased FMD.Conclusion: Pioglitazone significantly improves endothelial and adipose tissue dysfunction in pre-diabetic patients with CAD. (C) 2011 Elsevier Ireland Ltd. All rights reserved.