Optical methods in vascular biology and medicine.
Optical methods in vascular biology and medicine.
复制标题
血管生物学和医学中的光学方法。
DOI：
10.1117/1.3338696
复制
发表时间：
2010
影响因子：
3.5
通讯作者：
Jain,RakeshK
中科院分区：
文献类型：
--
作者：
Choi,Bernard;Bouma,Brett;Fukumura,Dai;Jain,RakeshK
当今的血管研究人员拥有一系列令人印象深刻的工具可供使用。光学技术的进步使得能够对脉管系统的解剖和功能状态进行非侵入性原位表征。具体来说，非线性光学显微镜和光学相干断层扫描（OCT）的发展使得对重要血管特征（例如易损斑块和肿瘤微循环）进行深度分辨、高分辨率成像成为可能。此外，不断增加的分子报告基因和转基因动物模型使研究人员能够以精确的特异性对血管特异性结构特征和功能状态（即基因表达）进行成像。本节关于血管医学中的光学方法，全面概述了光子技术和与心血管系统相关的重要生物学和生物医学问题的交叉研究。共有 14 篇优秀论文入选发表，其中 5 篇特邀文章回顾了使用各种光学技术的血管成像的现状：光声学（Hu 和 Wang）、功能光学显微镜（Salazar Vazquez 等人）、心血管 OCT（Tanaka、Tearney 和 Bouma）、荧光寿命显微镜（Marcu）和宽视野激光散斑对比成像（Boas 和 Dunn）。这
The present-day vascular researcher has an impressive array of tools at his/her disposal. Advances in optical techniques have enabled noninvasive, in situ characterization of the anatomic and functional state of the vasculature. Specifically, the development of nonlinear optical microscopy and optical coherence tomography (OCT) has enabled depth-resolved, high-resolution imaging of important vascular features such as vulnerable plaques and tumor microcirculation. Furthermore, the everincreasing number of molecular reporters and transgenic animal models has enabled researchers to image vascular-specific architectural features and functional states (ie, gene expression) with exquisite specificity.This special section on optical methods in vascular medicine serves as a comprehensive overview of research at the intersection of photonics technologies and important biological and biomedical problems related to the cardiovascular system. A total of 14 outstanding papers were selected for publication, including five invited articles which review the current state of vascular imaging using a variety of optical techniques: photoacoustics (Hu and Wang), functional optical microscopy (Salazar Vazquez et al.), cardiovascular OCT (Tanaka, Tearney, and Bouma), fluorescence lifetime microscopy (Marcu), and wide-filed laser speckle contrast imaging (Boas and Dunn). The