Vascular and myometrial changes in the human uterus at term
Vascular and myometrial changes in the human uterus at term
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DOI：
10.1177/1933719107309646
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发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
Smith, Roger
中科院分区：
文献类型：
--
作者：
Leong, Anthony S. -Y;Norman, Jane E.;Smith, Roger
在足月，羊水内容物可能通过激活羊水巨噬细胞及其迁移到子宫肌层介导分娩的开始。为了验证这一概念，作者检查了分娩前（n = 53）和分娩期间（n = 15）足月子宫肌瘤活检中发生的组织学变化。活检用抗巨噬细胞抗体、抗cd34（内皮细胞）和抗caspase 3（凋亡细胞）染色。样本显示中性粒细胞和巨噬细胞的不同炎症浸润，在分娩过程中获得的样本中浸润更大(P
At term, amniotic fluid contents may mediate the onset of labor through the activation of amniotic fluid macrophages and their migration into the myometrium. To test this concept, the authors examine the histological changes that occur in myometrial biopsies at term prior to (n = 53) and during (n = 15) labor. Biopsies were stained with an antimacrophage antibody, anti-CD34 (endothelial cells), and anti-caspase 3 (apoptotic cells). The samples showed a variable inflammatory infiltrate of neutrophils and macrophages, with a greater infiltrate in the samples obtained during labor (P