Synthesis, isolation and characterisation of β-sitosterol and β-sitosterol oxide derivatives
Synthesis, isolation and characterisation of β-sitosterol and β-sitosterol oxide derivatives
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DOI：
10.1039/b505069c
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发表时间：
2005-01-01
影响因子：
3.2
通讯作者：
Maguire, AR
中科院分区：
文献类型：
--
作者：
McCarthy, FO;Chopra, J;Maguire, AR
beta-Sitosterol is the most prevalent plant cholesterol derivative (phytosterol) and can undergo similar oxidation to cholesterol, leading to beta-sitosterol oxides. The biological impact of phytosterol oxides has only been evaluated in a phytosterol blend (usually of beta-sitosterol, campesterol, stigmasterol and dihydrobrassicasterol). The lack of pure phytosterols, including beta-sitosterol, hinders the collection of significant toxicity data on the individual beta-sitosterol oxides. An efficient synthetic route to multi-gram quantities of pure beta-sitosterol is described here, together with the first syntheses and characterisation of pure beta-sitosterol oxides.
