Coagulase-Negative Staphylococcal Infections in Vascular Surgery: Epidemiology and Pathogenesis
Coagulase-Negative Staphylococcal Infections in Vascular Surgery: Epidemiology and Pathogenesis
复制标题
血管手术中凝固酶阴性葡萄球菌感染：流行病学和发病机制
DOI：
--
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
G. Seabrook
中科院分区：
文献类型：
--
作者：
C. Edmiston;D. Schmitt;G. Seabrook
摘要人工血管葡萄球菌感染是外周血管手术的一种相对少见的并发症，然而，这些感染及其后遗症可能是灾难性的。大多数人工移植物感染是由表皮葡萄球菌的粘蛋白产生菌株引起的，其表达对合成基质的不同程度的粘附。研究表明，移植物的成分和结构特征、植入部位、抗菌剂给药和内源性微生物植物群均为血管移植物感染的可识别风险因素。粘蛋白的产生，一个已知的毒力因子，最近已被证明发生在内源性凝固酶阴性葡萄球菌（CNS）在入院时。虽然粘蛋白的产生在移植物感染的持续性中起着重要作用，但没有证据表明粘蛋白与抗菌素耐药性之间存在关系。（CNS）移植物感染的识别特征可能包括引流伤口窦道、移植物结合不良、移植物周围渗出物或吻合部位的假性动脉瘤。这些感染的隐匿性，其中病人往往是无症状的，使诊断和治疗困难。当采用常规培养方法时，移植物或移植物渗出液可能是阴性的。CNS移植物感染的识别需要高度怀疑，这些感染的治疗需要了解致病过程，个体化手术管理和抗菌药物的明智使用。
Abstract Staphylococcal infection of a vascular prosthesis is a relatively uncommon complication of peripheral vascular surgery; however, these infections and their sequelae can be catastrophic. The majority of prosthetic graft infections are caused by mucin-producing strains of Staphylococcus epidermidis, which express varying degrees of adherence to the synthetic substrates. Studies have demonstrated that the components and construction characteristics of the graft, implantation site, administration of antimicrobial agents, and endogenous microbial flora are all identifiable risk factors in vascular graft infections. Mucin production, a known virulence factor, has recently been shown to occur in endogenous coagulase-negative staphylococci (CNS) at the time of hospital admission. While mucin production plays an important role in the persistence of graft infections, there is no evidence that suggests a relationship between mucin and antimicrobial resistance. Identifying characteristics of (CNS) graft infections may include a draining wound sinus, poor graft incorporation, a perigraft exudate or a pseu-doaneurysm at the anastomotic site. The occult nature of these infections, in which the patient is often asymptomatic, makes diagnosis and treatment difficult. The graft or graft exudate may be negative when routine culture methods are employed. The recognition of CNS graft infections requires a high index of suspicion and the treatment of these infections requires understanding of the pathogenic process, individualized surgical management, and the judicious use of antimicrobial agents.
从脑脊液分流中分离出的凝固酶阴性葡萄球菌：粘液产生、物种鉴定和分流去除对临床结果的重要性。
DOI：
10.1093/infdis/156.4.548
发表时间：
1987
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Younger,JJ;Christensen,GD;Bartley,DL;Simmons,JC;Barrett,FF
通讯作者：
Barrett,FF