Small bowel bacterial overgrowth in subjects living in residential care homes.
Small bowel bacterial overgrowth in subjects living in residential care homes.
复制标题
居住在养老院的受试者的小肠细菌过度生长。
DOI：
10.1093/ageing/28.2.181
复制
发表时间：
1999
期刊：
影响因子：
6.7
通讯作者：
R. Mountford
中科院分区：
文献类型：
--
作者：
Stephen;J.;Lewis;Lindsay;F.;Potts;R. Malhotra;R. Mountford
目标
在老年人中，小肠细菌过度生长可能是隐匿性的。呼气测试呈阳性的意义尚不确定：许多健康状况良好、测试呈阳性的老年受试者没有显示出吸收不良的证据。我们评估了相对未经选择的老年人群中小肠细菌过度生长的患病率和意义。
方法
对7名老人院的居民进行了葡萄糖氢呼气测试。记录病史和拟人化测量结果。呼气测试呈阳性的志愿者接受了多西环素治疗。 4个月后，所有志愿者都接受了重新评估。
结果
140 名居民中，有 62 人接受了检测。九人 (14.5%) 呼气测试呈阳性。呼吸测试呈阳性和阴性的人之间的拟人化和排便习惯数据没有差异。经过 4 个月的抗生素治疗后，呼气测试呈阳性的志愿者体重和体重指数增加，而呼气测试阴性的志愿者体重和体重指数下降。
结论
呼气测试呈阳性的志愿者比例比之前的研究要低得多。这可能是由于志愿者相对未经选择的性质。细菌过度生长的治疗导致人体测量指数出现小幅但显着的改善。呼气测试阳性与基线拟人化测量或排便习惯缺乏关联，凸显了细菌过度生长的神秘性，并质疑其临床重要性。
OBJECTIVES
in elderly people, bacterial overgrowth of the small bowel may be occult. The significance of positive breath tests are uncertain: many fit elderly subjects with positive tests show no evidence of malabsorption. We assessed the prevalence and significance of bacterial overgrowth in the small bowel in a relatively unselected elderly population.
METHODS
residents of seven elderly people's homes had a glucose hydrogen breath test. A medical history and anthropomorphic measurements were recorded. Volunteers with positive breath tests were given doxycycline. After 4 months all volunteers were reassessed.
RESULTS
of 140 residents, 62 were tested. Nine (14.5%) had a positive breath test. There was no difference in anthropomorphic and bowel habit data between those with positive and those with negative breath tests. After 4 months of antibiotic treatment, volunteers with a positive breath test had increased weight and body mass index, while those with a negative test had decreased weight and body mass index.
CONCLUSIONS
the percentage of volunteers with a positive breath test was much lower than in previous studies. This may be due to the relatively unselected nature of the volunteers. Treatment of bacterial overgrowth resulted in a small but significant improvement in anthropometric indices. The lack of association of positive breath tests with baseline anthropomorphic measurements or bowel habit highlights the occult nature of the bacterial overgrowth and questions its clinical importance.
葡萄糖吸收不良与肠道快速运输有关。
DOI：
--
发表时间：
1992
期刊：
The American journal of gastroenterology
影响因子：
--
作者：
Sellin,JH;Hart,R
通讯作者：
Hart,R